Abstract: FTY-720, a new kind of immunosuppressant, 2-amino2-［2-(4-octylphenyl)ethyl-1,3-propanediol hydrochloride was synthesized via Friedelcrafts acylation, reduction, acylation, alkylation and Et₃SiH/ TiCl₄ reduction as a pivotal step from the starting material benzene or Friedel crafts acylation, alkylation, Et₃SiH/ TiCl₄ reduction and reduction as a pivotal step from the starting material phenethyl alcohol respectively and the total yield of the FTY-720 was 17% or 21% respectively. The structure of the target molecule and the key intermediates were confirmed by IR, ¹H NMR, ¹³C NMR and MS in our experiments. The route is simpler, more efficientand convenient that may be applied to industrial production.

Key words: synthesis, FTY720, medicinal chemistry, immunosuppressant