Abstract: Gelatin microspheres were prepared by means of emulsion chemicalcrossline technique. In order to gain the best homogeneous size and p arameters, it was demonstrated that solidifying reagent adding time had effects on gelatin microspheres. The preparation conditions of the microspheres such as gelatin concentration, agitate rate, ratio of water to oil phase were studied and discussed. The surface morphology and the size of the microspheres were observed by SEM. The result shows that the microspheres prepared have relatively uniform diameter, the average diameter in this study is 13.72 μm, and the surface of the microspheres is smooth.

Key words: gelatin, microsphere, emulsion chemicalcrossline technique, solidifying reagent, orthogonaldesigning method