红车轴提取物对基质金属蛋白酶的抑制活性

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Inhibition of Trifolium Pratense Extract to Matrix Metalloproteinases Activity

WANG Shuying¹,², JIANG Kun², YANG Jingang², PU Lihua³, LI Cong¹, SHEN Yehua¹, FANG Xuexun²

1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Institute of Drug Discovery, College of Chemistry and Material Science, Northwest University, Xi’an 710069, China;2. Key Laboratory of Molecular Enzymology and Enzyme Engineering of the Ministry of Education, Jilin University,Changchun 130021, China; 3. Xi’an Children Hospital, Xi’an 710003, China

Received:2008-04-07 Revised:1900-01-01 Online:2009-01-26 Published:2009-01-26
Contact: FANG Xuexun

Abstract

Abstract: To study the inhibition mechanism of Trifolium pratense to tumor, we investigated the inhibitory activity of Trifolium pratense extract contain 40% flavonoids and four major isoflavones on MMP-16. Results show that the Trifolium pratense extract containing 40% flavonoids inhibits MMP-16 a ctivity, biochanin A, genistein and daidzein can’t inhibit MMP-16 activity, formon onetin can weakly inhibit MMP-16 activity but not dosedependent. After column chromatography analysis, we obtained 33 fractions, the No.13 fraction and No.25 fraction inhibit MMP-16 activity and the inhibitory effect is dosedependent for the No.13 fraction.

Key words: Trifolium pratense extract, MMP-16, MMPs inhibitor

CLC Number:

R285.5

WANG Shuying,, JIANG Kun, YANG Jingang, PU Lihua, LI Cong, SHEN Yehua, FANG Xuexun. Inhibition of Trifolium Pratense Extract to Matrix Metalloproteinases Activity[J].J4, 2009, 47(01): 150-153.

Inhibition of Trifolium Pratense Extract to Matrix Metalloproteinases Activity

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