Abstract:

Apoptosis of pancreatic β cell RINm-5F was induced by glucose coupled with sodium palmitate. Effects of DhHP-6 or/and Exenatide on the apoptosis of RINm-5F cell were detected by methyl thiazolyl tetrazolium (MTT) assay. DhHP6 and Exenatide decreased the apoptosis induced by Glu-Pal significantly without no synergistic effect between them. In addition, we also found that DhHP6 and Exenatide both stimulated the proliferation of RINm-5F cells, and there was a synergistic effect between them.

Key words: DhHP-6, Exenatide, pancreatic β cell, synergistic effect