氨基化的介孔二氧化硅纳米材料与pDNA作用

Abstract

Abstract:

This work evaluated the adsorption and protection capacities of aminofunctionalized mesoporous silica nanoparticles (Am-MSNs) for pDNA （PEGFP-N3）. The in vitro biocompatibilities of AmMSNs to A549 and Hela cells were also tested, respectively. The results reveal that the Am-MSNs
exhibit good adsorption capacity for PEGFPN3. Moreover, the material can also protect PEGFPN3 from enzymatic degradation completely. In addition, the
sample presents high in vitro biocompatibilities to HeLa and A549 cells.

Key words: amino-functionalized mesoporous silica nanoparticle(Am-MSNs), pDNA, adsorption, protection, biocompatibility

CLC Number:

O641.2

ZHENG Kun, YANG Hong, GE Yakun, SUI Xin， WEN Gang, ZHANG Yuanxin. Aminofunctionalized Mesoporous SilicaNanoparticles Interacting with pDNA[J].Journal of Jilin University Science Edition, 2015, 53(06): 1316-1320.

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Aminofunctionalized Mesoporous SilicaNanoparticles Interacting with pDNA

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