Abstract:

Aiming at the problem of the abnormal change of the related parameters in the mathematical model of neuron, we first made a real time estimation of these key parameters by unscented Kalman filter (UKF), and then took these parameters as feedback signal of the controller to complete closed loop control of the neuron discharge. With this method, the MATLAB simulation was carried out for the abnormal discharge caused by the key parameters (the conductance
between cell bodies and dendrites gc, and the stimulated currents of dendrites Ic) of PinskyRinzel （PR）neuron, and the control of abnormal discharge caused by single parameter and two parameters were achieved respectively. The experimental results show the proposed method is effective.

Key words:  closed loop control, estimate of parameter, slow variable, key parameters