Journal of Jilin University Science Edition
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ZHAO Tianyi, CHEN Yun, YIN Yanchun, XING Shu, FU Xueqi
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Genomic DNA was extracted from peripheral blood of 91 patients with myeloproliferative neoplasms (MPNs) and 1 028 healthy volunteers (both Chinese). Using allele specific PCR (ASP) technique, we detected the genotype of rs12343867 and rs10974944 loci of the JAK2 haplotype 46/1 as protein tyrosine kinase. And combined with clinical data, we used SNPstats software for statistical analysis. Experimental results show that the probability of JAK2 haplotype 46/1 in MPNs patients was significantly higher than that in healthy volunteers (P<0.000 1); MPNs patients with JAK2 haplotype 46/1 are more likely to appear in the JAK2V617F mutation positive MPNs patients (n=70, P<0.000 1); the risk of MPNs in the Chinese population with JAK2 haplotype 46/1 is significantly increased, which is consistent with the results of the test in Europe and the United States.
Key words: JAK2 gene haplotype 46/1, Chinese population, JAK2V617F, myeloproliferative neoplasms (MPNs), allele specific PCR (ASP)
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ZHAO Tianyi, CHEN Yun, YIN Yanchun, XING Shu, FU Xueqi. Effect of JAK2 Gene Haplotype 46/1 on Susceptibility toMyeloproliferative Neoplasms in Chinese Population[J].Journal of Jilin University Science Edition, 2016, 54(02): 396-400.
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http://xuebao.jlu.edu.cn/lxb/EN/Y2016/V54/I02/396
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