基于灰值区间的微阵列模拟数据生成算法

Journal of Jilin University Science Edition

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An Algorithm for Generation of Simulated MicroarrayData Based on Grey Value Interval

XIA Xuefei^1,2, HAN Xiao³, LAN Tianshu¹, WANG Lihua⁴, WU Jianan⁵, ZHOU You¹

1. College of Computer Science and Technology, Jilin University, Changchun 130012, China;2. College of Electronic Information, Jilin Communications Polytechnic College, Changchun 130012, China；3. Editorial Department of Journal of Jilin University, Changchun 130012, China;4. Faculty of Information Science and Arts, Osaka ElectroCommunication University, Osaka 5750063, Japan;5. College of Computer Science and Technology, Changchun University, Changchun 130022, China

Received:2016-07-26 Online:2016-11-26 Published:2016-11-29
Contact: ZHOU You E-mail:zyou@jlu.edu.cn

Abstract

Abstract: Aiming at the problem of large data acquisition and high cost of microarray chip, we proposed a new algorithm for generation of simulated microarray data based on grey value interval. The algorithm simulated differential expression of genes in microarray data by means of grey value measurement, combined with cluster analysis method to create a cluster tunnel, and then generated simulation data with similar mathematical distribution and biological significance of the original data. The algorithm was verified and analyzed by simulated data and real biological data. Experimental results show that the simulation data generated by the concept of grey value interval and the generation mechanism of cluster tunnel is effective and reliable.

Key words: simulated data, cluster analysis, differentially expressed genes, microarray data, sample

CLC Number:

TP393

XIA Xuefei, HAN Xiao, LAN Tianshu, WANG Lihua, WU Jianan, ZHOU You. An Algorithm for Generation of Simulated MicroarrayData Based on Grey Value Interval[J].Journal of Jilin University Science Edition, 2016, 54(06): 1401-1404.

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An Algorithm for Generation of Simulated MicroarrayData Based on Grey Value Interval

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