Abstract: Taking Caenorhabditis elegans (C.elegans)  as a model, we studied the effect of mint extracts on the stress resistance, and further studied the mechanism of mint extract against ultraviolet (UV) irradiation. The results show that  mint extracts can significantly increase the resistance of C.elegans to  UV-irradiation，P.Aeruginosa infection， 35 ℃ heat shock，  and juglone oxidation. The mint extracts can significantly reduce the level of reactive oxygen species (ROS)  and increase activity of superoxide dismutase (SOD) in C.elegans   after UV-irradiation. It can also play a role  through insulin/IGF-1-like signaling pathway, increase the mRNA expression  levels of the sod-3，hsp-12.6，hsp-16.1， and hsp-16.49  of the downstream transcription factor of the pathway, and increase the number of nuclear localization of transcription factor daf-16. The mint extracts can increase the motility and swallowing ability of C.elegans, but do not affect their lifespan and fertility.

Key words: mint； , stress resistance； , Caenorhabditis elegans