Abstract: The  commonly available and stable catalysts and phosphorus ligands were used  as the catalytic system, we optimized the reaction system of  palladium-catalyzed copper-free Sonogashira coupling  to prepare β-(2-phenylethynyl)cyclobutanone compounds.  We obtained a series of alkynyl cyclobutanone compounds with different functional groups in high yields. Furthermore, the ring-opening-metathesis of these compounds catalyzed by copper was realized.

Key words:  , Sonogashira reaction, o-alkynylphenylcyclobutanone, Pd-catalyst, Lewis acid, cyclization reaction