Abstract: In order to study the effects of human to human diffusion, spatial heterogeneity and different concentrations of Vibrio in static water source environment on cholera transmission, we established  a partially degenerated reaction-diffusion cholera model. Firstly, we defined the basic reproduction number R₀ of the model. Secondly, the global threshold dynamics of the model was determined by the sign of R₀-1. Finally, we discussed  the effects of key model parameters on R₀ through numerical simulation experiments. The results show that moderate urbanization is beneficial to disease control.

Key words: vibrio cholerae, spatial heterogeneity, basic reproduction number, global threshold dynamics