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Studies on chloromethylation of acetanilide and its derivatives

YU Li-jun1, NING Zhao-lun2, WANG En-si1,2, ZHANG Fu-zhong3, YANG Shi-zhong4   

  1. 1. College of Pharmacy, Jilin University, Changchun 130021, China; 2. College of Life Science, Jilin University, Changchun 130021, China; 3. Tongliao Entry-Exit Inspection and Quarantine Breau, Tongliao 028000, China; 4. College of Changchun Chinese Medicine Attach Hospital, Changchun 130021, China
  • Received:2003-02-20 Revised:1900-01-01 Online:2004-01-26 Published:2004-01-26
  • Contact: WANG En-si

Abstract: The chloromethylation of acetanilide and its derivatives in a polyformaldehyde-HCl system gave N-substituted products as the major product. The structures of the intermedi ates and the target molecule were confirmed by H NMR and 13C NMR spectra in our experiments.

Key words: acetanilide, derivative, chloromethylation, reaction

CLC Number: 

  • O621.26