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Preparation and Characterization of CdTe@SiO2@GdF3Fluorescence/Magnetic Resonance ImagingDual Functional Microsphere#br#
JIN Li, LIU Fangtong, LI Wei, ZHANG Jianpo
Journal of Jilin University Science Edition. 2018, 56 (6):
1549-1555.
CdTe@SiO2 microspheres were synthesized by modified Stber method, and then CdTe@SiO2@GdF3fluorescence/magnetic resonance imaging dual functional microsphere with core/shell structure were prepared by direct precipitation method. Furthermore the structure, magnetic resonance imaging and fluorescence property were characterized by transmission electron microscope (TEM), energy dispersive Xray analysis (EDXA), magnetic resonance imaging (MRI), Fourier transform infrared spectroscopy (FT-IR) and fluorescence spectrum. The experimental results show that the synthesized microsphere has obvious spherical core/shell structure, a large number of GdF3 dispersed well on the surface of silica in the form of small particles, and the particle sizes are 5—8 nm. Si,O and Gd elements can be detected on the surface of CdTe@SiO2@GdF3 microsphere, and Gd has been doped into the CdTe@SiO2 materials. Compared with CdTe quantum dots, the fluorescence emission spectra of CdTe@SiO2@GdF3 microspheres have a red shift, but still have good fluorescence property. The relaxation parameter r1 of CdTe@SiO2@GdF3 microspheres is 3.48 s-1/(mmol·L-1), so the synthesized CdTe@SiO2@GdF3 microspheres can be used for T1weighted magnetic resonance imaging. When mass concentration of CdTe@SiO2@GdF3 is 200 μg/mL, the cell viability is still above 90%, indicating that the toxicity of the microphere on cells is weak.
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