关键词: 毒性, 肺, 病理学, 脂质过氧化作用, 谷胱甘肽过氧化酶

Abstract: Objective To study the effects of formaldehyde on lung histomorphology and the level of lipid peroxide in mice after inhaled different amount of formaldehyde. Methods Forty male mice were randomly divided into 4 groups: one control group and three formaldehyde dose groups(20，40, and 80 mg•m-3). The mice were poisoned 2 hours one day for 5 weeks continuously, then were killed. Lung tissues of mice inhaled formaldehyde were observed under light microscopy (LM). The activity of superoxide dismutase (SOD) and content of malondialdehyde (MDA) were detected biochemically in lung homogenate. Results It was manifestated as becoming bloodshots of pulmonary alveoli, expansion of pulmonary alveolus segment and inflammatory cells invasion under LM. The activities of SOD in 20,40, and 80 mg•m-3 dose groups were significantly lower than that in the control group, and the concentration of MDA was remarkably higher (P<0.01). The activity of SOD and the concentration of MDA had no remarkable differences between the different dose groups(P>0.05),but the former showed an increase activity in different dose groups, and the latter showed a reduced concentration in different dose groups. Conclusion Formaldehyde can injury free radical eliminated system to cause lung injury.

Key words: toxicity, lung, pathology, lipid peroxidation, glutathione peroxidase