Objective： To investigate the expressions of miR-1915-3p and Bcl-2 mRNA in colon cancer tissue and their relationships with the clinicopathological parameters and prognosis of the colon cancer patients， and to clarify the roles of miR-1915-3p and Bcl-2 in the occurrence and development of colon cancer.Methods
A total of 40 colon cancer specimens and paired paracancer normal mucosa tissue were collected for examination of miR-1915-3p and Bcl-2 mRNA expression levels by Real-time fluorescence quantitative polymerase chain reaction （RT-qPCR）. The correlation between the miR-1915-3p expression level and Bcl-2 mRNA expression level was analyzed by Pearson correlation analysis. The correlations between the expressions of miR-1915-3p and Bcl-2 and the clinicopathological features and prognosis of the colon cancer patients were analyzed by χ2 test. The survival curve was drawn by Kaplan-Meier method， and the survival difference was tested by Log-rank test.Results
The RT-qPCR results showed that compared with the adjacent mucosa tissue， the expression level of miR-1915-3p in colorn cancer tissue was decreased significantly （P<0.05）， and the expression level of Bcl-2 mRNA in colon cancer tissue was increased （P<0.05）； there was a significant negative correlation between the expression level of miR-1915-3p and the expression level of Bcl-2 mRNA in colon cancer tissue （r=－0.542，P<0.05）. The expression lervels of miR-1915-3p in colon cancer tissue was significantly correlated with the degree of tumor differentiation and lymph node metastasis （P<0.05）， but not with gender， age， tumor size and TNM stage （P>0.05）. The expression level of Bcl-2 mRNA in colon cancer tissue was significantly correlated with TNM stage （P<0.05）， but was not related to other clinicopathological features （P>0.05）. The Kaplan-Meier analysis results of survival curve showed that the overall survival（OS） of the colon cancer patients in miR -1915-3p high expression group was lower than that in miR-1915-3p low expression group （χ2=3.641，P<0.05）. There was no significant relationship between the expression level of Bcl-2 mRNA and the prognosis of colon cancer patients （χ2=0.571，P>0.05）.Conclusion
The miR-1915-3p expression level in tumor tissue of the colorectal cancer patients is decreased， but the expression level of Bcl-2 mRNA is significantly increased. The combined detection of them is useful for the diagnosis and prognosis evaluation of colon cancer.