正常妊娠妇女和妊娠高血压综合征患者血浆中肾上腺髓质素的测定

doi:吉林省科学技术委员会资助课题

正常妊娠妇女和妊娠高血压综合征患者血浆中肾上腺髓质素的测定

阮利红¹，李静波¹，潘宇²，苑爱军³，何凯^△，朱凤全^1*

1. 吉林大学第二医院妇产科，吉林长春 130041；2. 长春市中心医院妇产科,吉林长春 130051；3. 解放军65316部队医院外科, 吉林长春130051

收稿日期:2003-07-25 修回日期:1900-01-01 出版日期:2004-03-28 发布日期:2004-03-28
通讯作者: 朱凤全

Determination of plasma adrenomedullin in normal pregnantwomen and pregnancy-induced hypertension patients

RUAN Li-hong¹, LI Jing-bo¹，PAN Yu²,YUAN Ai-jun³,HE Kai^△,ZHU Feng-quan^1*

1. Department of Obstetrics and Gynecology,Second Hospital, Jilin University,Changchun 130041, China；2. Department of Obstetrics and Gynecology, Central Hospital of Changchun,Changchun 130051, China；3. Department of Surgery, No.65316 Hospital of PLA, Changchun 130051, China

Received:2003-07-25 Revised:1900-01-01 Online:2004-03-28 Published:2004-03-28
Contact: ZHU Feng-quan

摘要/Abstract

摘要： 目的：探讨血浆肾上腺髓质素（ADM）与生理妊娠及妊娠高血压综合征(妊高征)之间的关系。方法：应用放射免疫法测定10例正常非孕妇女、36例正常妊娠妇女（早、中、晚期各12例）和30例妊高征患者（轻、中、重度各10例）血浆ADM浓度，所得数据行统计学分析。结果：正常妊娠各阶段ADM水平均高于非妊娠妇女(P<0.05)，妊高征组血浆ADM高于正常晚期妊娠组(P<0.01)，轻、中、重度妊高征患者血浆ADM水平之间比较差异有显著性(P<0.05)。妊高征患者的平均动脉压与ADM水平呈正相关（r=0.822，P<0.01)，低体重儿发生与妊高征的严重程度有关。结论：ADM参与维持人类正常妊娠。在妊高征发病机制中，ADM可能是代偿性升高。

关键词: 妊娠, 妊娠并发症, 心血管

Abstract: Objective To study the relationships between plasma adrenomedullin (ADM) and normal pregnancy and pathogenesis of pregnancy-induced hypertension(PIH) . Methods ADM concentrations in the plasma from 10 normal non-pregnant women,36 normal pregnant women (12 first,12 second,12 third trimester, respectively) and 30 cases of PIH (10 mild,10 moderate,10 severe, respectively) were determined by radioimmunoassay, and data were analyzed statistically. Results ADM concentrations in the first, second and third trimester of normal pregnancy increased significantly than that of normal non-pregnant women (P<0.05). ADM concentration in the plasma of patierts with PIH was higher than that of third trimester pregnancy (P<0.01). There were significant differences between mild, moderate, and severe PIH groups (P<0.05). In the PIH groups, significant positive correlation was found between plasma ADM concentration and mean arterial pressure(r=0.822,P<0.05). Incidence of low birth weight infants was related to serious degree of PIH. Conclusion ADM may involve in maintaining normal human pregnancy. ADM may increase compensatorily in the pathogenesis of PIH.

Key words: pregnancy, pregnancy complications, cardiovascular

中图分类号:

R714.25

阮利红，李静波，潘宇，苑爱军，何凯，朱凤全. 正常妊娠妇女和妊娠高血压综合征患者血浆中肾上腺髓质素的测定[J]. J4, 2004, 30(2): 264-266.

RUAN Li-hong, LI Jing-bo，PAN Yu,YUAN Ai-jun,HE Kai,ZHU Feng-quan. Determination of plasma adrenomedullin in normal pregnantwomen and pregnancy-induced hypertension patients[J]. J4, 2004, 30(2): 264-266.

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