顶端动脉瘤的血流动力学数值模拟速度分析

doi:国家自然科学基金

顶端动脉瘤的血流动力学数值模拟速度分析

陈旭东¹，付方雪¹，杨新建²，吴中学²，陈东¹，陈洪¹，胡继良¹，吴耀晨¹，罗琪^3*

1. 暨南大学第二临床医学院神经外科深圳市人民医院神经外科，广东深圳518020；2. 北京市神经外科研究所，北京100050;3. 吉林大学第一医院神经外科，吉林长春130021

收稿日期:2004-10-16 修回日期:1900-01-01 出版日期:2005-07-28 发布日期:2005-07-28
通讯作者: 罗琪

Hemodynamic numerical simulation and velocity analysis of intracranial terminal aneurysms

CHEN Xu-dong¹, FU Fang-xue¹, YANG Xin-jixue²,CHEN Dong¹,CHEN Hong¹,HU Ji-liang¹,WU Yao-chen¹，LUO Qi^3*an²,WU Zhong

1. Department of Neurosurgery, Second Medical College,Ji′nan University, Shenzhen 518020,China;2. Beijing Institute of Neurosurgery,Beijing 100050,China;3. Department of Neurosurgery, First Hospital,Jilin University,Changchun 130021,China

Received:2004-10-16 Revised:1900-01-01 Online:2005-07-28 Published:2005-07-28
Contact: Qi

摘要/Abstract

摘要： 目的：探讨顶端动脉瘤的血流动力学特点，分析动脉瘤生长、破裂的可能机制。方法：采用计算流体力学（CFD）软件结合顶端动脉瘤的医学影像，对动脉瘤内血液流动行数值模拟。结果：脉动状态下每个心动周期里，在0~0.4 s内速度变化最剧烈，在动脉分叉处形成涡运动。通过瘤颈进入动脉瘤内时，血流速度骤减，在动脉瘤中央形成涡，速度逐渐减小并可能静止。瘤顶血流速度很小甚至静止。结论：顶端动脉瘤血流动力过程复杂，血管分叉处涡运动剧烈；瘤颈速度在0~0.5 s内剧烈变化，受到血流的冲击瘤颈扩大使瘤生长；破裂主要在瘤顶，但是瘤顶速度很小甚至静止，瘤壁在血流冲击下的振荡是破裂的因素之一。速度是危险因子之一，0~0.5 s是危险时间窗。

关键词: 计算流体力学, 数值模拟

Abstract: Objective To investigate the hemodynamic characteristics of intracranial terminal aneurysms and analysis the possible mechanism of growth and rupture of intracranial aneurysms. Methods Some images of intracranial terminal aneurysms were handled by some image processing software. The profile meshed by some computational fluid dynamics (CFD) software were used to simulate the flow. Results From the beginning to 0.4 s of every cardiac cycle, the velocity had a sharp change and vortex existed across the inlet in unsteady condition. The velocity decreased and came into be nearly stagnant when it acrossed the aneurysm neck and vortex came into being inside aneurysm. The velocity of the distal end of aneurysm was very slow and sometime its value was zero. Conclusion The hemodynamics of terminal aneurysms is very complex. The velocity in the neck has a sharp change and vortex exist during the period of 0-0.5 s. Under the impact of blood stream，the aneurysm neck begins to append and the aneurysm comcs to grow or rupture. It always happens in the distal end of aneurysm，but the velocity is very slow. Maybe the oscillation work was a risk factor for aneurysm rupture.

Key words: computational fluid dynamics, mumerical simulation

中图分类号:

R743

陈旭东，付方雪，杨新建，吴中学，陈东，陈洪，胡继良，吴耀晨，罗琪. 顶端动脉瘤的血流动力学数值模拟速度分析[J]. J4, 2005, 31(4): 498-500.

CHEN Xu-dong, FU Fang-xue, YANG Xin-jixue,CHEN Dong,CHEN Hong,HU Ji-liang,WU Yao-chen，LUO Qian,WU Zhong. Hemodynamic numerical simulation and velocity analysis of intracranial terminal aneurysms[J]. J4, 2005, 31(4): 498-500.

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[2]	陈旭东，罗祺，罗毅男，赵刚，付方雪，胡继良，吴耀晨. 顶端动脉瘤的血流动力学数值模拟切应力分析[J]. J4, 2005, 31(3): 381-383.