海洛因对大鼠肝功能血浆酶学的影响

doi:吉林省科技厅资助课题  （200505229）;吉林

海洛因对大鼠肝功能血浆酶学的影响

崔佳乐，孙婷，张连芝，李奇，石立红，洪敏

（吉林大学基础医学院生物化学与分子生物学教研室，吉林　长春　130021）

收稿日期:2006-11-06 修回日期:1900-01-01 出版日期:2007-11-28 发布日期:2007-11-28
通讯作者: 洪敏

Effect of heroin on enzyme in plasma of liver function in rats

CUI Jia-yue,SUN Ting,ZHANG Lian-zhi,LI Qi,SHI Li-hong,HONG Min 

(Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China )

Received:2006-11-06 Revised:1900-01-01 Online:2007-11-28 Published:2007-11-28
Contact: HONG Min

摘要/Abstract

摘要： 目的：研究海洛因依赖大鼠肝功能的变化。方法：采用逐渐递增剂量法腹腔注射海洛因，建立海洛因依赖及戒断大鼠模型，50只建模成功Wistar大鼠随机分成对照组、给药3 d组、给药9 d组、戒断3 d组及戒断9 d组，检测各组大鼠血液生化指标天门冬氨酸氨基移换酶（AST）、丙氨酸氨基移换酶（ALT）及γ-谷氨酰基移换酶（GGT）。结果：与对照组比较，给药3 d组ALT的含量明显下降（P<0.05），给药9 d组ALT的含量下降更为显著（P<0.01），戒断3 d组ALT的含量上升显著（P<0.01）;给药9 d组GGT的含量显著下降（P<0.01）。与给药9 d组相比，戒断 3 d组AST的血浆含量显著升高（P<0.01）；戒断3 d、9 d组的ALT血浆含量均显著升高（P<0.01）；戒断3 d组血浆GGT含量明显升高（P<0.05），戒断9 d组血浆GGT含量升高更为显著（P<0.01）。结论：海洛因对肝功能的损害有延迟性及持续性，且不能在停药后立即消除。

关键词: 天门冬氨酸氨基移换酶, 丙氨酸氨基移换酶, γ-谷氨酰移换酶, 肝功能

Abstract: To investigate the changes of liver function in heroin dependent rats.MethodsUsing intraperitoneal injection with increasing doses to establish rat models of heroin administration and withdrawal.50 Wistar rats were randomly divided into five groups: control,3 d administration group,9 d administration group,3 d withdrawal group and 9 d withdrawal group.The levels of aspartate aminotransferase (AST),alanine aminotransferase (ALT) and γ-glutamyl transpeptidase (GGT) in plasma were tested.ResultsCompared with control group,the level of ALT in 3 d withdrawal group decreased significantly (P<0.01),the level of ALT in 3 d administration group decreased significantly (P<0.05),the level of ALT in 9 d administration group decreased even significantly(P<0.01),the level of ALT in 3 d withdrawal group increased apparently(P<0.01)；and the level of GGT in 9 d administration group decreased apparently. Compared with 9 d administration group,the level of AST in 3 d withdrawal group increased apparently (P<0.01),the levels of ALT both in 3 d and 9 d withdrawal groups increased apparently(P<0.01）,the level of GGT in 3 d withdrawal group increased apparently (P<0.05),and the level of GGT in 9 d withdrawal group increased even apparently (P<0.01). ConclusionThe heroin has detention and durative damage to the liver function,and can’t be eliminated immediately after drug withdrawal.

Key words: aspartate aminotransferase, alanine aminotransferase, gamma- glutamyltranspeptidase, function of the liver

中图分类号:

R-332

崔佳乐，孙婷，张连芝，李奇，石立红，洪敏. 海洛因对大鼠肝功能血浆酶学的影响[J]. J4, 2007, 33(6): 986-988.

CUI Jia-yue,SUN Ting,ZHANG Lian-zhi,LI Qi,SHI Li-hong,HONG Min . Effect of heroin on enzyme in plasma of liver function in rats[J]. J4, 2007, 33(6): 986-988.

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