神经肽Y与神经降压素改变及比例失调在高血压发病中的作用

doi:吉林省科技厅资助课题(20050408)

神经肽Y与神经降压素改变及比例失调在高血压发病中的作用

纪文新¹，张远卓¹，邱杰^{△^{,秦玲^２}}

1.北华大学附属医院循环科，吉林吉林132011；2.吉林大学第一医院心内科吉林长春　130021

收稿日期:2006-04-13 修回日期:1900-01-01 出版日期:2006-09-28 发布日期:2006-09-28

Clinical significance of changes and ratio imbalance of neuropeptide Y and neurotensin in patients with essential hypertension

JI Wen-xin¹, ZHANG Yuan-zhuo¹, QIU Jie^△, QIN　Ling2

1. Department of Circulation Medicine,Affilicated Hospital,Beihua University,Jilin 132011,China;2.Department of Cardiology,First Hospital,Jilin University,Changchun 130021,China

Received:2006-04-13 Revised:1900-01-01 Online:2006-09-28 Published:2006-09-28

摘要/Abstract

摘要： 目的：探讨血浆中神经肽Y（NPY）和神经降压素（NT）两者比例失调在原发性高血压（EH）发病中的作用。方法：采用放射免疫分析法（RLA）检测176例EH患者血浆中的NPY和NT水平，同时设正常对照组（n=84）。结果：EH患者血浆中的NPY水平明显高于对照组（P<0.01)，并随病情加重而升高（P<0.01)；NT水平明显低于对照组（P<0.01),并随病情的加重而下降（P<0.01)；NPY/NT比值高于对照组（P<0.01),与病情相一致。结论：NPY、NT参与了高血压病的发病过程。NPY/NT比例失调可能是EH发病机制之一。

关键词: 神经肽Y, 神经降压肽

Abstract: Objective To study the effects of changes of neuropeptide Y(NPY) and neurotensin(NT) concentrations in plasma and their ratio imbalance on the incidence of essential hypertension (EH).Methods NPY and NT in plasma in 176 patients with EH were measured with radioimmunoassay(RIA). Results NPY in the EH patients was higher than that in the normal subjects (P<0.01), and went up with the aggravation of the patients′condition( P<0.01).NT in the EH patients was lower compared with the normal subjects (P<0.01), and went down with the aggravation of the patients′ condition ( P<0.01). NPY/NT in the EH patients was higher than that in the normal subjects (P<0.01), and was accordant with patients′ condition. Conclusion NPY and NT are involved in the incidence of EH.The ratio imbalance of NPY/NT may be one of the factors causing EH.

Key words: neuropeptide Y, neurotensin

中图分类号:

R544.1

纪文新，张远卓，邱杰,秦玲. 神经肽Y与神经降压素改变及比例失调在高血压发病中的作用[J]. J4, 2006, 32(5): 866-868.

JI Wen-xin, ZHANG Yuan-zhuo, QIU Jie, QIN　Ling. Clinical significance of changes and ratio imbalance of neuropeptide Y and neurotensin in patients with essential hypertension[J]. J4, 2006, 32(5): 866-868.

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