关键词: 万古霉素, 翻修术, 人工髋关节

Abstract: Objective To study the anti-infection effects of VCM-PMMA femoral prosthesis on revision after sheep hip arthroplasty. Methods Right lateral femoral replacement on thirty Inner Mongolia sheep was taken. Gelatin sponge, having methicillin resistant staphylococcus aureus (MRSA), was implanted in the right hip. Three weeks later, the model of infected hip after arthroplasty was established in sheep. VCM-PMMA prosthesis (experimental group) and PMMA prosthesis (control group) were implanted in the right hip after the debridement. The infection control rate, the pathological changes of soft tissue and the prosthesis position were observed in the two groups after the internal of five weeks. Results The rate of infection in the right hip joints was 100% on the third week. After five weeks, the rate of infection control was 93.33% in experimental group; the rate of infection control was 33.33% in control group, the difference was significant between two groups(χ² =12.36, P<0.05). The prosthesis was on the good place by the X-ray. Pathological section was observed under microscope. Neutrophilic granulocytes were hardly found in the experimental group. Neutrophilic granulocytes were much in control group. Conclusion The anti-infection effects of VCM-PMMA prosthesis on revision after sheep hip arthroplasty are very significant.

Key words: vancomycin, revision, artifical hip joint