吉林大学学报(医学版)

• 基础研究 • 上一篇    下一篇

荞麦糠皮提取物对2型糖尿病大鼠心肌损伤的保护作用

勾向博1,郭 静2,王银环3,艾凌艳4,韩淑英1   

  1. 1.河北联合大学基础医学院药理学教研室，河北 唐山 063000；2.河北联合大学实验研
    究中心，河北 唐山 063000；3.河北联合大学机能实验室，河北 唐山 063000；4.河北联合大学理学院物理教研室，河北 唐山 063000
  • 收稿日期:2013-03-06 发布日期:2013-12-12
  • 通讯作者: 韩淑英(Tel：0315-3725870,E-mail：shuyinghan59@126.com) E-mail:shuyinghan59@126.com
  • 作者简介:勾向博(1984-)，女，河北省沧州市人，助教，医学硕士，主要从事心血管药理学的研究。
  • 基金资助:

    河北省科技厅科技计划项目资助课题（122077175D）；河北省自然科学基金资助课题
    （C2010001795）；河北联合大学科学研究基金资助课题（Z2001128）

Protective effect of extract of buckwheat chaff 
on myocardial injury of type 2 diabetic rats

GOU Xiang-bo1,GUO Jing2,WANG Yin-huan3,AI Ling-yan4,HAN Shu-ying1   

  1. 1.Department of Pharmacology，Hebei United University,Tangshan 063000,China;2.Medical Experimental
     and Research Center，Hebei United University,Tangshan 063000,China;3.Functional Laboratory，Hebei 
    United University,Tangshan 063000,China;4.Department of Physics,College of Science,Hebei  United 
    University,Tangshan 063000,China
  • Received:2013-03-06 Published:2013-12-12

RichHTML

0

PDF (PC)

413

赞

摘要：

目的：探讨荞麦糠皮提取物（EBC）对2型糖尿病（T2DM）大鼠心肌损伤的保护作
用，并阐明其保护作用机制。方法：采用小剂量链脲佐菌素（STZ）加高糖高脂饲料喂养的方
法建立大鼠T2DM模型。建模成功的23只T2DM大鼠分为模型对照组（n=8）、EBC治疗组（n=7）和贝那普利治疗组（n=8）,
另取7只SD大鼠作为正常对照组。EBC治疗组和贝那普利治疗组大鼠分别给予EBC（200 mg?kg-1?d-1）和贝那普利（4 mg/kg-1 /d-1）
灌胃；正常对照组和模型对照组大鼠分别给予纯水（10 mL?kg-1?d-1）。灌胃给药8周后，检测各组大鼠体质量（BW）、心脏质量指数（HWI）、空腹血糖（FBG）水平和左室收缩压（LVSP）、左心室舒张期末压（LVEDP）、心率（HR）、左室内压最大上升下降速率（±dp/dtmax）；光镜下观察各组大鼠心肌组织形态学改变。结果：与正常对照组比较，模型对照组大鼠FBG、HWI、LVEDP升高(P<0.01)，BW、LVSP、HR和±dp/dtmax下降(P<0.05或P<0.01)；与模型对照组比较，EBC治疗组和贝那普利治疗组大鼠BW、LVSP、HR、±dp/dtmax明显升高(P<0.05或P<0.01)；而HWI、FBG和LVEDP显著降低(P<0.05或P<0.01)；EBC治疗组和贝那普利治疗组大鼠心肌组织形态得到改善。结论：EBC可以改善T2DM大鼠心脏组织学形态，其机制可能为通过上调LVSP、HR和±dp/dtmax、下调LVEDP而改善心功能。

关键词:  , 荞麦, 糠皮提取物, 2型糖尿病, 血糖, 心功能

Abstract:

Objective  To study the protective effect of extract of buckwheat chaff (EBC mellitus) on myocardial injury in  type 2 diabetes mellitus (T2DM)
 rats and  to disscuss its mechanism.Methods T2DM rat  models were established  by injecting streptozotocin (STZ) and given high-fat diet.
23 T2DM rats were divided into model control group (n=8),EBC treatment group (n=7),and benazepril treatment group (n=8).Another 7 SD rats were selected as normal control group.The rats in EBC treatment group and benazepril treatment group were administered with EBC （200 mg/kg-1/d-1）
and benazepril （4 mg /g-1/d-1）orally.While the rats in other two groups were administered with　normal water (10 mL/kg-1/d-1) instead.The levels of fasting blood glucose (FBG),body weight (BW),cardiac index (HWI),heart rate (HR),left ventricular systolic blood pressure(LVSP),left ventricular dia stolic pressure(LVEDP) and ±dp/dtmax
　of  rats were measured 8 weeks after treatment  in various  groups.The  morphological  changes of myocardium tissue of  rats were observed with light
microscope.Results Compared with normal control group,the FBG,HWI,LVEDP of the rats  in model group were increased(P<0.01), and the BW,LVSP,HR,and ±dp/dtmax in model control groups were decreased(P<0.05 or P<0.01).Compared with model control group,the BW,LVSP,HR,and ±dp/dtmax were i
ncreased and the  HWI,FBG and LVEDP  of the rats in EBC and benazepril treatment groups were decreased(P<0.05 or P<0.01).The morphology of myocardium tissue
of  the rats in EBC treatment and benazpril treatment groups were improved.Conclusion EBC can improve the histomorphology  of myocardium tissue of the T2DM rats,and its mechanism may be related to up-regulating  the  LVSP,HR and ±dp/dtmax and down-regulating  the  LVEDP.

Key words:  , buckwheat, extract of buckwheat chaff, type 2 diabetes mellitus, glucose, cardiac function

中图分类号: 

  •  
版权所有 © 《吉林大学学报(医学版)》编辑部
地址：长春市新民大街828号(130021)　电话：+86-431-85619279　E-mail: xuebao@jlu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发