吉林大学学报(医学版)

• 基础研究 • 上一篇    下一篇

每搏变异度和中心静脉压对肝叶切除术患者低血容量的诊断价值比较

谢 海1,赵建农2,陈 勇3,周 期1,李 艳3   

  1. 1.海南医学院附属医院麻醉科,海南 海口 570102;2.海南省人民医院神经外科,海南 海口 570311;3.海南省人民医院麻醉科,海南 海口 570311
  • 收稿日期:2013-03-03 发布日期:2013-12-12
  • 通讯作者: 李 艳(Tel: 0898-66528117,E-mail: hnxh2003@163.com) E-mail:hnxh2003@163.com
  • 作者简介:谢 海(1979-),男,海南省海口市人,主治医师,医学硕士,主要从事重症监护方面的研究。
  • 基金资助:

     海南省卫生厅科研基金资助课题(琼卫2011-44)

Comparison of diagnostic values between stroke volume variation and central venous pressure in low circulatory  blood volume of patients undergoing partial hepatectomy

XIE Hai1,ZHAO Jian-nong2,CHEN Yong3,ZHOU Qi1,LI Yan3   

  1. 1.Department of Anesthesiology,Affiliated Hospital, Hainan Medical College,Haikou 570102,China;2. Department of Neurosurgery,Hainan Provincial People’s Hospital,Haikou 570311,China;3. Department of Anesthesiology,Hainan Provincial People’s Hospital,Haikou 570311,China
  • Received:2013-03-03 Published:2013-12-12

摘要:

目的: 比较每搏变异度(SVV)和中心静脉压(CVP)与临床低血容量状态的相关性,探讨其对低血容量的诊断价值。 方法: 选择120例择期
肝部分切除手术患者,在全麻插管机械通气下手术开始后,分别以1、2和3 μg?kg-1?min-1为剂量递增,静脉泵注硝酸甘油,检测前后4个时点[输注前即刻(T0),硝酸甘油1 μg?kg-1?min-1输注15 min后(T1),硝酸甘油2 μg?kg-1?min-1输注15 min后(T2),硝酸甘油3 μg?kg-1?min-1输注15 min后(T3)]患者的SVV、CVP、平均动脉压(MAP)、心率(HR)、每搏量指数(SVI)、体循环阻力指数(SVRI)和心指数(CI)。采用受试者工作特征(ROC)曲线计算SVV和CVP对CI反应曲线下面积(AUC)、灵敏度与特异度之和最高值;采用Pearson等级相关分析法分析SVV和CVP与CI的相关性。 结果: CVP和SVV对CI反应的AUC分别为AUCCVP 0.713(95%CI 0.623~0.804)、AUCSVV 0.930(95%CI 0.883~0.977);SVV值为12.5%时,敏感度与特异度之和最大,其敏感度为81%,特异度为95%;CVP为5.5 mmHg时,敏感度与特异度之和最大,其敏感度为73%,特异度为59%;AUCSVV高于AUCCVP(P<0.05);SVV、CVP与CI相关系数SVV-CI=-0.671(95%CI -0.455~-0.67);rCVP-CI=0.551(95%CI 0.744~0.591);rSVV-CI 与rCVP-CI 比较差异无统计学意义(P>0.05)。结论: SVV和CVP均是低血容量诊断的良好指标;SVV比CVP对低血容量预见性更高,对低血容量诊断的敏感度和特异度更高。

关键词:  , 每搏变异度, 中心静脉压, 低血容量, 硝酸甘油

Abstract:

Objective To explore the diagnostic values of stroke volume variation (SVV) and central venous pressure (CVP)   in low circulatory
blood volume by comparing  the correlations between SVV,CVP and low circulatory blood volume.Methods 120 patients undergoing partial hepatectomy were randomly selected.After general anesthesia with endotracheal intubation and the begining of the operation, nitroglycerin was administered to the patients via vein  with three separate stages of the dosage regimen of 1,2,and 3 μg?kg-1?min-1.The hemodynamic variables including  stroke volume variation (SVV),central venous pressure (CVP),mean arterial pressure (MAP),heart rate (HR),stroke volume index (SVI),cardiac index (CI) and systemic vascular resistance index (SVRI) of the patients  were detected at 4 time points:before infusion (T0),15 min after infusion of nitroglycerin 1 μg?kg-1?min-1 (T1),15 min after infusion of  2 μg?kg-1?min-1 nitroglycerin(T2),15 min after infusion of  3 μg?kg-1?min-1 nitroglycerin  (T3).The maximum of sensitivity and  specificity and   the receiver operating characteristic curve (AUC) of SVV and CVP  responding to CI were detected byoperating characteristic (ROC) curve; Pearson rank correlation method was used to analyze  the correlation between SVV, CVP and CI.Results The AUC of SVV and CVP responding to CI were AUCCVP 0.713 (95%CI, 0.623-0.804) and AUCSVV 0.930 (95%CI, 0.883-0.977).When the SVV was 12.5%,the sum of sensitivity and specificity was the biggest with  ensitivity of 81% and  specificity of 95%;when the  CVP was 5.5 mmHg,the sum of sensitivity and specificty was the biggest with   sensitivity of 73% and  specificity of 59
%. The value of AUCSVV was larger than that of AUCCVP (P<0.05).The values of Pearson’s correlation coefficient of SVV,CVP and CI were rSVV-CI=-0.671
(95%CI -0.455--0.67)and rCVP-CI= 0.551(95%CI 0.744-0.591) and there were no significant difference between rSVV-CI  and rCVP-CI (P>0.05).
Conclusion SVV and CVP are good parameters for diagnosis of low circulatory blood volume variation.The predictability of SVV for low circulatory blood volume is higher than CVP,and SVV is more sensitive and specific.

Key words: stroke volume variation, central venous pressure, low circulatory blood volume, nitroglycerin

中图分类号: 

  •