微量元素硒对急性病毒性心肌炎患儿脂质过氧化损伤的影响

doi:吉林省卫生厅科研基金资助课题

微量元素硒对急性病毒性心肌炎患儿脂质过氧化损伤的影响

郑百红，毓明涛，郑百波^△，姜桂英^*

吉林大学第二医院儿科，吉林长春130041

收稿日期:2002-12-05 修回日期:1900-01-01 出版日期:2004-05-28 发布日期:2004-05-28
通讯作者: 姜桂英

Effect of selenium on lipid peroxidation damagein children with acute viral myocarditis

ZHENG Bai-hong, YU Ming-tao, ZHENG Bai-bo^△, JIANG Gui-ying^*

Department of Pediatrics, Second Hospital, Jilin University, Changchun 130041, China

Received:2002-12-05 Revised:1900-01-01 Online:2004-05-28 Published:2004-05-28
Contact: JIANG Gui-ying

摘要/Abstract

摘要： 目的：探讨氧自由基（OFR）在急性病毒性心肌炎（AVMC）发病中的作用及硒（Se）制剂对OFR损伤心肌的治疗作用。方法：将60例患儿作为VMC组，60例健康儿童作为对照组。测定两组血硒(Se)、谷胱甘肽过氧化物酶(GSH-P_X)、超氧化物歧化酶（SOD）、丙二醛（MDA）水平。将60例AVMC患儿随机分为补硒组(30例)和常规治疗组(30例)。补硒组30例在心肌炎常规治疗（抗病毒、调节免疫、能量合剂、维生素C营养心肌）基础上补硒治疗，常规治疗组30例给予心肌炎常规治疗，疗程4周。观察两组治疗前后血Se、GSH-P_X、 SOD、 MDA，并结合心肌酶、心电图、临床表现进行疗效判定。结果：AVMC患儿体内的氧自由基反应和脂质过氧化反应呈病理性变化。60例AVMC患儿血Se、SOD、GSH-P_X降低（P<0.001），MDA值升高（P<0.001），补硒组治疗后较治疗前血Se、SOD、GSH-P_X明显升高（P<0.01、P<0.01、P<0.001），MDA值明显降低（P<0.001），临床症状全部消失，心肌酶恢复正常，心电图恢复正常百分率明显高于常规治疗组（P<0.05）。结论：Se通过清除氧自由基，抑制脂质过氧化反应而保护心肌，提高AVMC患儿治愈率，在常规治疗基础上加Se治疗AVMC优于常规治疗。

关键词: 心肌炎, 脂质过氧化作用, 活性氧

Abstract: Objective To study the action of oxygen free radical (OFR) in pathogenesis of acute viral myocarditis (AVMC) and the therapeutic effect of selenium (Se) on myocardium damaged by OFR. Methods Se in serum, superoxide dismutase (SOD), glutathione peroxidase (GSH-P_X)，malonadelye (MDA) were detected in children, which included 60 cases of AVMC children and 60 healthy children as control, respectively. Children with AVMC were randomly divided into routine treatment group (30 cases) and Se-supplemented group (30 cases). Se-supplemented and routine treatment (anti-viruses, immune system modulation, myocardium nourishing) were used in Se-supplemented group. Only routine treatment was used in routine treatment group. The treatment period was 4 weeks. Through observation of changes of Se in serum, GSH-P_X，SOD，MDA，enzyme of myocardium, ECG and clinical symbols before and after treatment in two groups, the curative effects were assessed. Results OFR and LPO reactions appeared pathological changes in children with AVMC. Se in serum，SOD，GSH-P_X were decreased (P<0.001) and MDA was increased (P<0.001) in children with AVMC. After treatment with Se-supplemented, Se in serum, SOD，GSH-P_X activities were significantly increased (P<0.01, P<0.01,P<0.001)and MDA content was significantly decreased (P<0.001)， compared with before treatment, and all of the clinical symbols were disappeared. Enzymes of myocardium were normal. The percentage of ECG normalization was significantly higher than that of the routine treatment group (P<0.05). The curative rate of AVMC was increased. Conclusion Se is effective to clear OFR and able to protect myocardium through inhibiting OFR and LPO reaction. On the basis of routine treatment for viral myocarditis, Se-supplemented is more effective than routine treatment.

Key words: myocarditis, Lipid peroxidation, reactive oxygen species

中图分类号:

R725.4

郑百红，毓明涛，郑百波，姜桂英. 微量元素硒对急性病毒性心肌炎患儿脂质过氧化损伤的影响[J]. J4, 2004, 30(3): 437-440.

ZHENG Bai-hong, YU Ming-tao, ZHENG Bai-bo, JIANG Gui-ying. Effect of selenium on lipid peroxidation damagein children with acute viral myocarditis[J]. J4, 2004, 30(3): 437-440.

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