静脉血栓患者FⅫ　C46T基因多态性分析

doi:吉林省科技厅科技发展计划项目资助课题（20

静脉血栓患者FⅫ　C46T基因多态性分析

张桂荣¹，于艳辉²，陈光³，吴山力¹，曲成刚¹，赵文光³

1.吉林大学基础医学院生物化学教研室, 吉林长春 130021；2.吉林大学第二医院检验科, 吉林长春 130041；3.吉林大学第一医院血管外科, 吉林长春 130021

收稿日期:2006-09-22 修回日期:1900-01-01 出版日期:2007-05-28 发布日期:2007-05-28
通讯作者: 赵文光

Analysis of C46T gene polymorphism of FⅫ in patients with venous thrombosis patients

ZHANG Gui-rong¹，YU Yan-hui¹，CHEN Guang²，WU Shan-li¹，QU Cheng-gang¹，ZHAO Wen-guang³

1.Department of Biochemistry, School of Basic Medical Sciences， Jilin University,Changchun 130021,China；2.Department of Laboratory,Second Hospital，Jilin University,Changchun 130041,China；3.Department of Vascular Surgery,First Hospital，Jilin University,Changchun 130021,China

Received:2006-09-22 Revised:1900-01-01 Online:2007-05-28 Published:2007-05-28
Contact: ZHAO Wen-guang

摘要/Abstract

摘要： 目的：探讨凝血因子Ⅻ（FⅫ）基因第一外显子C46T基因多态性与静脉血栓形成的关联性。方法：应用PCR-RFLP分析方法检测87例静脉血栓患者和129例健康对照的FⅫ基因外显子C46T基因型及其频数分布，采用多元Logistic非条件回归方法分析FⅫ基因第一外显子C46T基因多态性与静脉血栓形成的关联性。 结果：在研究人群中存在有FⅫ 46C/C、C/T、T/T 3种基因型，静脉血栓患者中的FⅫ 46C/C基因型频数分布（6.90%）高于健康对照人群（4.65%）。经多元Logistic非条件回归分析，FⅫ 46C/C基因型与深静脉血栓无关联性（χ²=1.036，P=0.309，OR=1.86，95%CI：0.57～6.12）。结论: 不能确定FⅫ基因第一外显子C46T基因多态性是静脉血栓形成的危险因素，静脉血栓形成与FⅫ基因第一外显子C46T基因多态性的关联性有待于深入研究。

关键词: 多态现象(遗传学), 静脉血栓形成

Abstract: Abstract:Objective To explore the association between the C46T gene polymorphism in the exon-1 region of the coagulation factorⅫ(FⅫ) and venous thrombosis. Methods PCR-RFLP method was used to investigate the distribution frequency of the C46T gene polymorphism in the 87 venous thrombosis patients and 129 healthy controls.The relation of the C46T gene polymorphism with venous thrombosis was analyzed by Logistic un-conditional regression.Results There were three kinds of genotypes including 46C/C,46C/T,46T/T in the study population.The distribution frequency of 46C/C genotype in the venous thrombosis patients (6.9%) was higher than that in the healthy controls(4.65%).There was no relativity between 46C/C genotype and venous thrombosis.（χ²=1.036，P=0.309，OR=1.86，95%CI：0.57—6.12）.Conclusion It is not deemed that the C46T gene polymorphism of FⅫ is an independent risk factor in the venous thrombosis and the relativity between the deep venous thrombosis and C46T gene polymorphism is going on research.

Key words: polymorphism (genetics), venous thrombosis

中图分类号:

R543.6

张桂荣，于艳辉，陈光，吴山力，曲成刚，赵文光. 静脉血栓患者FⅫ　C46T基因多态性分析[J]. J4, 2007, 33(3): 555-558.

ZHANG Gui-rong，YU Yan-hui，CHEN Guang，WU Shan-li，QU Cheng-gang，ZHAO Wen-guang. Analysis of C46T gene polymorphism of FⅫ in patients with venous thrombosis patients[J]. J4, 2007, 33(3): 555-558.

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