关键词: 炎性因子IL-6, M-CSF, 球囊损伤

Abstract: Abstract:Objective To observe the effects of ilexonin A (IA) on IL-6 and M-CSF following ballon angioplasty in rabbit common carotide artery to provide experimental basis for percutaneous coronary interventions. Methods 30 Japanese rabbits were fed with high cholesterol food for 4 weeks. Then they were divided into three groups randomly. Each group had ten rabbits. ①Control group: the incision was sew directly after right carotide artery of the rabbit was seeked. ②Balloon dilation group:the proximal of the carotide artery was cuted,the ballon was delivered and distended,after it was drawn repeatly,the incision was closed. ③IA therapy group: operation was the same to the balloon dilation group,then IA was administered in vein.All of them were fed with high cholesterol diet for 4 weeks and the blood samples were collected 1 d before the operation and 1 d,1,2,4 weeks after the operation. The serum IL-6 and M-CSF levels were determined with radioimmunoassay.The pathological changes of injuried artery were observed. Results ①The IL-6 level in balloon dilation group was higher than that in IA therapy group after the operation (P<0.05),and came back later to preoperation level. ②Though the M-CSF level in IA therapy group was increased, but it was lower than that in dilation group (P<0.05) and the time of returning to preoperation level was obviously earlier than that in balloon dilation group (P<0.05). ③The pathological results demonstrated that the artery endothelial in control group was smooth and no foam cell in sight.In bolloon dilation group,the endangium was thickened,the vascular smooth muscle cells proliferated,there were many foam cells and the lumen was constrictive.In IA therapy group,the number of foam cells reduced,the constrictive degree of lumen was alleviated.Conclusion IA can redece the levels of serum IL-6 and M-CSF and inhibit the proliferation of vascular smooth muscle cells following ballon angioplasty.

Key words: IL-6, M-CSF , ballon damage