关键词: ^131<, sup>I治疗, 复发, 乏氧诱导因子-1α

Abstract: To research the relationship between hypoxia-inducible factor-1 alpha(HIF-lα) expression and the recurrence of differentiated thyroid carcinoma(DTC) after complete thyroidectomy combined with ¹³¹I treatment，and explore its possible mechanism of recurrence. Methods The recurrence rate of 173 cases of DTC after complete thyroidectomy within 3 years was analyzed,according to the follow-up detecting data of Tg,TgAb,B-mode ultrasonography,X-ray scanning and global ¹³¹I imaging,the cases of recurrence were used as recurrence group,the same number cases without recurrence as control group which were chosen randomly.The HIF-lα expressions in recurrence cancer tissues and un-recurrence cancer tissues were detected with immunohistochemical staining and RT-PCR technique. Results The 3-year recurrence rate after thyroidectomy was 5.20%(9/173),among them, the recurrence rate of papillary carcinoma was 4.90%(5/102),while the recurrence rate of follicle carcinoma was 5.63%(4/71),there was no significant difference between two groups (P>0.05).The HIF-lα expression levels in recurrence tissues of papillary carcinoma and follicle carcinoma were significantly higher than those in unrecurrence tissues (P<0.05).Conclusion Several recurrence cases can be still found in DTC cases after complete thyroidectomy combined with ¹³¹I treatment,one of its mechanisms may be related to significant increase of the HIF-lα expression level in cancer tissue.

Key words: ^131<, sup>I treatment, recurrence, HIF-lα