关键词: 实验性, 金属硫蛋白, 脂类, 代谢, 锌, 铜, 大鼠, Wistar

Abstract: Objective To detect the effects of MT egg-milk powder on blood glucose and blood lipid level and serum zinc,copper levels in diabetic rats.Methods Sixty Wistar rats were randomly divided into normal control group(CON,n=10),diabetic group(DM,n=10),positive control group(POS,n=10)and high,middle,low doses of MT egg-milk powder groups (DM+MT,n=10)with doses of 10.0,5.0,2.5 g•kg^-1.After the rats were injected intraperitoneally with streptozosin(STZ) to establish DM models,the rats were treated with MT egg-milk powder for 40 d;the blood glucose,blood lipid level and the zinc,copper levels were observed.Results At the end of the experiment，compared with DM group, high and middle doses of MT egg-milk powder decreased triglycerides(TG),cholesterol (CHO) and low density lipoprotein(LDL) levels（P<0.05）,but high-density lipoprotein (HDL) were significantly elevated（P<0.01）.Low dose of MT decreased LDL level(P<0.01),and raised HDL level（P<0.05）.The serum zinc and copper levels were significantly elevated（P<0.05）in middle and low DM+MT groups compared with DM group.Conclusion MT egg-milk powder can morderate the lipid metabolism and enhance the serum zinc level.

Key words: experimental, metallothionein , lipids, metabolism, zinc, rats, Wistar