A total of 70 healthy male C57BL/6J mice were adaptively fed for 1 week， 10 mice were randomly selected as control group， and the remaining 60 mice were used to establish T2DM mouse model according to the method of high-fat diet combined with intraperitoneal injection of low dose streptozotocin （STZ）. Fifty mice were randomly selected from 52 mice that were successfully modeled and divided into model group， low， medium， and high doses of RRP groups， and metformin group； with 10 mice in each group.The mice were administered once a day for 10 weeks； the mice in control group and model group were given equal volumes of normal saline by gavage. During the experiment， the general state of mice was observed every day， the fasting blood glucose （FBG） level was monitored weekly， and oral glucose tolerance test （OGTT） was performed every 4 weeks. After continuous treatment for 10 weeks，the area under time-glucose curve（AUC） of OGTT and the insulin resistance index（HOMA-IR） of the mice in various groups were calculated.The levels of serum fasting insulin （FINS）， C-peptide， and glucagon （GC） and the pancreatic mitochondrial function-related indicators were detected. The pancreas tissue of mice in various groups was obtained，the pancreatic indexes were calculated，and the pathomorphology of pancreas tissue of mice in various was observed by HE staining.

Compared with control group， the mice in model group were apathetic， with rough hair and decreased voluntary activity； compared with model group， the mice in different doses of RRP groups and metformin group had better mental state， with shiny hair and increased voluntary activities. Compared with control group， the body mass of the mice in model group was significantly decreased （P<0.05）， the amount of drinking water and food intake were significantly increased （P<0.05）， and the serum FBG level， AUC of OGTT and HOMA-IR were significantly increased （P<0.05）； compared with model group， the body mass of the mice in medium and high doses of RRP groups was increased significantly （P<0.05）， the amounts of drinking water and food intake were decreased significantly （P<0.05）， and the AUC of OGTT was significantly decreased （P<0.05）， the serum levels of FBG and HOMA-IR of mice in different doses of RRP groups were significantly decreased （P<0.05）. Compared with control group， the serum levels of FINS and C-peptide of the mice in model group were significantly decreased （P<0.05）， the GC level was significantly increased （P<0.05）， and the pancreatic index， respiratory control rate（RCR）， and basal respiratory oxygen consumption and ADP/O were significantly decreased（P<0.05）； compared with model group， the serum FINS and C-peptide levels of the mice in medium and high doses RRP groups and metformin group were significantly increased （P<0.05）， the GC levels were significantly decreased （P<0.05）， ADP/O and RCR were significantly increased （P<0.05）， and the pancreatic indexes and basal respiratory oxygen consumption of the mice in different doses of RRP groups and metformin group were significantly increased （P<0.05）. Compared with control group， the shape of islets in the pancreas tissue of the mice in model group was irregular， and the size and number of islet cells were significantly reduced， accompanying with by inflammatory infiltration and necrosis； compared with model group， the morphology of islets in the pancreas tissue of the mice in different doses of RRP groups was complete， the sizes and number of islets were increased， and the areas of necrosis were decreased.

RRP can improve the function of pancreatic mitochondria and increase the secretion of insulin， thereby regulating the blood glucose of T2DM mice.