多发性肌炎/皮肌炎并发甲状腺相关疾病患者临床特征分析

doi:10.13481/j.1671-587x.20160532

Abstract

Abstract:

Objective: To study the characteristics and clinical appearence of polymyositis(PM) or dermatomyositis(DM) combined with thyroid diseases, and to analyze the clinical significance. Methods: Total 77 patients first diagnosed as PM or DM were selected. All the patients were divided into four groups according to their thyroid functions, which were normal thyroid function group, low T3 syndrome group, hypothyroidism group, and subclinical hypothyroidism group. Their clinical manifestations, laboratory features, immunological examination results and prognosis were collected and analyzed. Results: In all the PM/DM patients, there were 41 cases with thyroid disfunction,including 17 cases(41.46%) with low T3 syndrome(41.46%). Compared with normal thyroid function group, the patients in hypothyroidism group were more vulnerable to dysphagia and edema (P<0.05); the proportion of proteinuria was also significantly increased (P<0.05). The PM/DM patients with low T3 syndrome were more easier to have higher incidence of death, higher level of C-reactive protein and lower levels of albumin and calciumion as well as higher incidence of edema and pleural effusion (P<0.05). Conclusion: The incidence of PM/DM combined with thyroid disfunction is higher, and low T3 syndrome is most common. The PM/DM patients with hypothyroidism and low T3 syndrome are more likely to suffer the digestive system, lung and kidney injuries. The patients with low T3 syndrome have a higher death rate.

Key words: polymyositis, dermatomyositis, thyroid function, clinical characteristics, prognosis

CLC Number:

R593.26

GU Sanwei, MA Hongshuang, ZHAO Ling, JIANG Zhenyu. Analysis on clinical characteristics of PM/DM combined with thyroid disease[J].Journal of Jilin University Medicine Edition, 2016, 42(05): 999-1004.

References

[1] Watad A, Cohen AD, Comaneshter D, et al. Hyperthyroidism association with SLE, lessons from real-life data-A case-control study[J]. Autoimmunity, 2016, 49(1):17-20.

[2] Rasaei N, Shams M, Kamali-Sarvestani E, et al. The prevalence of thyroid dysfunction in patients with systemic lupus erythematosus[J]. Iran Red Crescent Med J, 2015, 17(12):1-7.

[3] Costa CC, Medeiros M, Watanabe K, et al. Hashimoto thyroiditis may be associated with a subset of patients with systemic sclerosis with pulmonary hypertension[J]. Rev Bras Reumatol, 2014, 54(5):366-370.

[4] Biró E, Szekanecz Z, Czirják L, et al. Association of systemic and thyroid autoimmune disease[J]. Clin Rheumatol, 2006, 25(2):240-245.

[5] Szyper-Kravitz M, Marai I, Shoenfeld Y. Coexistence of thyroid autoimmunity with other autoimmune diseases:Friend or foe? Additional aspects on the mosaic of autoimmunity[J]. Autoimmunity, 2005, 38(3):247-255.

[6] Bohan A,Peter JB.Polymyositis and dermatomyositis[J].New Eng J Med, 1975, 292(7):344-347.

[7] 胡昕, 刘毅. 皮肌炎/多发性肌炎合并低T3综合征的临床意义[J]. 现代预防医学, 2010, 37(13):2584-2586.

[8] Wang H, Li H, Kai C, et al. Polymyositis associated with hypothyroidism or hyperthyroidism:two cases and review of the literature[J]. Clin Rheumatol, 2011, 30(4):449-458.

[9] Wang H, Tao L, Li H, et al. Dermatomyositis related to autoimmune thyroiditis[J]. J Eur Acad Dermatol Venereol, 2011, 25(9):1085-1093.

[10] 田小兰, 张思功, 舒晓明, 等. 皮肌炎合并甲状腺功能异常的临床分析[J]. 中华临床医师杂志:电子版, 2013, 7(3):1013-1017.

[11] 蔡云雅, 方红. 皮肌炎/多发性肌炎86例的甲状腺功能分析[J]. 中国皮肤性病学杂志, 2015, 29(4):365-367,374.

[12] Adler SM, Wartfsky L. The nonthyroidal illness syndrome[J]. Endonerinol Metab Clin North Am, 2007, 36(3):657-672.

[13] Warner MH,Beckett GJ. Mechanisms behind the non-thyroidal illness syndrome:an update[J]. JEndocrinol, 2010, 205(1):1-13.

[14] Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3:local thyroid hormone metabolism during inflammation and infection[J]. Endocr Rev, 2011, 32(5):670-693.

[15] Iervasi G, Pinqitoore A, Landi P, et al. Low T3 syndrome a strong prognostic predictor of death in patients with heart disease[J]. Circulation, 2003, 107(5):708-713.

[16] Dankó K, Ponyi A, Constantin T,et al. Long-term survival of patients with idiopathic inflammatory myopathies according to clinical features:a longitudinal study of 162 cases[J]. Medicine (Baltimore), 2004, 83(1):35-42.

[17] Bohan A, Peter JB, Bowman RL, et al. Computer assisted analysis of 153 patients with polymyositis and dermatomyositis[J]. Medicine (Baltimore), 1977, 56(4):255-286.

[18] Mebis L, van der Berghe G. Thyroid axis function and dysfunction in critical illness[J]. Best Pract Res Clin Endocrinol Metab, 2011, 25(5):745-757.

[19] Ohira H, Abe K,Takahashi A. Involvement of the liver in rheumatic diseases[J]. Clin J Gastroenterol, 2012, 5(1):9-14.

[20] Takahashi A, Abe K, Yokokawa J, et al. Clinical features of liver dysfunction in collagen diseases[J]. Hepatol Res, 2010, 40(11):1092-1097.

[21] Nagaraju K, Lundberg IE. Polymyositis and dermatomyositis:pathophysiology[J]. Rheum Dis Clin North Am, 2011, 37(2):159-171.

[22] Wu GC, Pan HF, Leng RX, et al. Emerging role of long noncoding RNAs in autoimmune diseases[J]. Autoimmun Rev, 2015, 14(9):798-805.

[23] Jenkins RC, Weetman AP. Disease associations with autoimmune thyroid disease[J]. Thyroid, 2002, 12(11):977-988.

[24] Selva-O' Callaghan A, Redondo-Benito A, Trallero-Araguás E, et al. Clinical significance of thyroid disease in patients with inflammatory myopathy[J]. Medicine (Baltimore), 2007, 86(5):293-298.

[25] Paul S, Li L, Kalaga R, et al. Characterization of thyroglobulin-directed and polyreactive catalytic antibodies in autoimmune disease[J]. J Immunol, 1997, 159(3):1530-1536.

[26] 陈梅卿,巫斌,孙华瑜,等.系统性红斑狼疮患者51例甲状腺功能临床分析[J].福建医科大学学报, 2006, 40(5):494-495.

[27] Fujita M, Hatachi S, Yagita M. Dermatomyositis associated with thyroid cancer[J]. Rheumatol Int, 2008, 29(2):203-205.

[28] Ikeda T, Kimura E, Hirano T, et al. The association between dermatomyositis and papillary thyroid cancer:a case report[J]. Rheumatol Int, 2012, 32(4):959-961.

[29] Lee JH, Kim SI.A case of dermatomyositis associated with papillary cancer of the thyroid gland[J]. Clin Rheumatol, 2005, 24(4):437-438.

Analysis on clinical characteristics of PM/DM combined with thyroid disease

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