Abstract:

 To observe the changes of  the formation of specific　antibodies,lymphocyte transformation and peritoneal macrophage phagocytotic function in mice after treated with La(NO3)3,and to explore  the effect of  La(NO₃)₃) on immune function in mice.Methods 60 Kunming mice were randomly divided into  control group,La(NO₃))₃) 0.1,0.2,2.0,10.0 and 20.0 mg·kg^－1 groups,there were 10 mice in each group,and the mice in various groups  were given  intraperitoneal injection of saline,La(NO3)3 0.1,0.2,2.0,10.0,and 20.0 mg·kg^－1 once a day.Direct agglutination,3H-TdR incorporation radiation self-developing technique and phagocytic chicken erythrocytes were used to detect the   anti-A-antibody titer,marked lymphocyte transformation ratio and ratio of  chicken erythrocytes  phagocytized by peritoneal macrophages after treated with La(NO3)3.Results Compared with control group,the anti-A antibody titer,the marked lymphocyte transformation ratio and the ratio  of chicken erythrocytes phagocytized by peritoneal macrophages of mice in  La(NO₃)₃ 0.1，0.2 and 2.0 groups were increased significantly(P<0.01);compared with control, La(NO3)3 0.1，0.2 and 2.0 groups,those indexes mentioned above in  La(NO₃)₃  10.0 and 20.0 mg·kg^-1groups were decreased significantly(P<0.01).Conclusion  Small doses of La(NO3)3 can promote the formation of specific antibodies,lymphocyte transformation and phagocytic function of peritoneal macrophages  and  large doses of La(NO3)3 have  significantly inhibitory effects in mice.

Key words: La(NO₃)₃ , anti-A antibody , autoradiography , macrophages