硼替佐米致多发性骨髓瘤患者急性肺损伤1例报告及文献复习

doi:10.13481/j.1671-587X.20210428

Abstract

Abstract: Objective

To investigate the pathogenesis， clinical manifestations and treatment strategies of bortezomib-induced acute lung injury in the patient with multiple myeloma，and to provide the reference for the diagnosis and treatment of this disease.

Methods

The clinical data of a patient with acute lung injury caused by bortezomib were collected， and the relevant literatures were summarized and reviewed.

Results

A 48-year-old male patient with multiple myeloma developed fever and dyspnea during the fourth course of VCD regimen （bortezomib， cyclophosphamide and dexamethasone）. The patient was diagnosed as bortezomib related acute lung injury by imaging examination， laboratory examination， etiology examination and bronchoscopy. On the premise of discontinuing bortezomib， the patient was given glucocorticoid and noninvasive ventilator assisted ventilation. After treatment， the patient’s condition was improved and the patient was discharged.

Conclusion

Bortezomib treatment-related acute lung injury has low incidence， rapid progress and high mortality， so it is particularly important to identify this kind of disease early. Early discontinuation of bortezomib and glucocorticoid can effectively reduce the mortality and improve the prognosis of suspected the patients.

Key words: multiple myeloma, bortezomib, lung toxicity, acute lung injury, noninvasive ventilator assisted ventilation

CLC Number:

R733.3

Qiao LI,Zhenzhong SU,Zhaoyong WANG,Yanling XU,Qun ZHANG,Peng GAO,Jie ZHANG. Bortezomib-induced acute lung injury in patient with multiple myeloma：A case report and literature review[J].Journal of Jilin University(Medicine Edition), 2021, 47(4): 1022-1027.

Figures/Tables 5

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References 19

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Bortezomib-induced acute lung injury in patient with multiple myeloma：A case report and literature review

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