多囊卵巢综合征病因及其发病机制的研究进展

doi:10.13481/j.1671-587X.20240136

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder closely associated with reproductive endocrine dysfunction in the women. The etiology and pathogenesis of PCOS remain unclear. PCOS is the result of the combination of endocrine metabolic disorders, genetics, and environmental factors. Hyperandrogenemia (HA) and insulin resistance (IR) are the fundamental pathophysiological changes in the development of PCOS, and their interactions exacerbate the clinical manifestations of the PCOS patients. The family aggregation and twin study results confirm the genetic predisposition of PCOS; the genome-wide association study (GWAS) results confirm some risk loci and candidate genes of PCOS. The unhealthy lifestyle habits and environmental endocrine disruptors also play an important role in the progression of PCOS, and the gut microbita is involved in the pathogenesis of PCOS. This article provides a comprehensively retrospective analysis on the recent studies about PCOS,and reviews both internal factors and external factors related to the etiology and pathogenesis of PCOS.

Key words: Polycystic ovary syndrome, Endocrine metabolic disorder, Gut microbiome, Inflammation, Environment, Genetics

CLC Number:

R711.75

Yajie GE,Wen XU,Shimin GUAN,Lina WANG. Research progress in etiology and pathogenesis of polycystic ovary syndrome[J].Journal of Jilin University(Medicine Edition), 2024, 50(1): 288-294.

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Research progress in etiology and pathogenesis of polycystic ovary syndrome

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