雪旺氏细胞迁移在外周神经损伤修复中作用的研究进展

doi:10.13481/j.1671-587X.20250431

Abstract

Abstract:

Peripheral nerve injury （PNI） is a common neurological disorder. As the primary constituent cells of the myelin sheath， Schwann cells （SCs） play a crucial role in the repairment process after PNI. After PNI， the SCs are activated and rapidly migrate to the injury site， forming a neural bridge that connects the proximal and distal stumps in conjunction with the endothelial cells， the extracellular matrix（ECM）， and the fibroblasts. This bridge provides a pathway for axonal regrowth and guides axonal regeneration. The ability of SCs to migrate quickly to the damaged nerve site is a key factor influencing the formation of the neural bridge. The ECM， NT， non-coding RNAs， particularly long non-coding RNAs （lncRNA） and microRNA （miRNA）， and various transcription factors regulate the migratory capacity of the SCs through multiple signaling pathways， thereby affecting the repair of PNI. However， to date， there has been no systematic study on the factors influencing the migration of SCs in PNI or their underlying mechanisms. This article comprehensively reviews the various factors affecting the migration of SCs after PNI， including the ECM， NT， non-coding RNAs， and transcription factors， as well as the related signaling pathways. It aims to provide the basis for systematically understanding the role of SCs in PNI repairment and to offer the reference for comprehensive analysis of the repairment mechanisms after PNI.

Key words: Schwann cells, Cell migration, Peripheral nerve injury, Repairment, MicroRNA, Long non-coding RNA

CLC Number:

R651.3

Wenxuan LI,Minru ZONG. Research progress in role of migration of Schwann cells in repairment of peripheral nerve injury[J].Journal of Jilin University(Medicine Edition), 2025, 51(4): 1137-1144.

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Research progress in role of migration of Schwann cells in repairment of peripheral nerve injury

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