降糖药物那格列奈的核磁共振谱解析

降糖药物那格列奈的核磁共振谱解析

尹建元¹，李桂英¹，王恩思¹,2

1.　吉林大学药学院，长春　130021； 2.　吉林大学生命科学学院，长春　130023

收稿日期:2002-07-17 修回日期:1900-01-01 出版日期:2003-01-26 发布日期:2003-01-26
通讯作者: 王恩思

Elucidation of Oral Hypoglycemic Drug Nateglinide by NMR

YIN Jian-yuan¹, LI Gui-ying¹， WANG En-si^1,2

1. College of Pharmacy, Jilin University, Changchun 130021, China; 2. College of Life Science, Jilin University, Changchun 130023, China

Received:2002-07-17 Revised:1900-01-01 Online:2003-01-26 Published:2003-01-26
Contact: WANG En-si

摘要/Abstract

摘要： 利用NMR法考查胰岛素分泌促进剂那格列奈的分子结构特征，采用DEPT， ^{1< /sup>Ｈ-¹Ｈ COSY和¹³C-¹Ｈ HETCOR等实验技术归属了那格列
奈的氢谱和碳谱.}

关键词: 那格列奈, 核磁共振, 光谱解析

Abstract: The NMR spectra were used for elucidating the structure of nateglinide , N-［(trans-4-isopropylcyclohexyl)-carbonyl］-D-phenylalanine, which is used as an oral hypoglycemic drug. By means of DEPT,¹Ｈ-¹Ｈ CO SY and ^1３C-¹Ｈ HETCOR techni ques, the proton and¹³Ｃ spectra of nateglinide were assigned co mpletely.

Key words: nateglinide, NMR, chemical structure elucidation

中图分类号:

O621.15

尹建元，李桂英，王恩思,2. 降糖药物那格列奈的核磁共振谱解析[J]. J4, 2003, 41(01): 120-122.

YIN Jian-yuan, LI Gui-ying， WANG En-si. Elucidation of Oral Hypoglycemic Drug Nateglinide by NMR[J]. J4, 2003, 41(01): 120-122.

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