吉林大学学报(理学版) ›› 2025, Vol. 63 ›› Issue (5): 1505-1515.

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多功能梭形Fe3O4@PDA纳米载体的制备与表征

王晓晖1,  刘景林1, 丁鑫1,2, 胡艳军2   

  1. 1. 内蒙古民族大学 化学与材料学院, 内蒙古 通辽028000; 2. 湖北师范大学 化学化工学院, 污染物分析与资源化技术湖北省重点实验室, 湖北 黄石435002
  • 收稿日期:2025-01-23 出版日期:2025-09-26 发布日期:2025-09-26
  • 通讯作者: 丁鑫 E-mail:dingx@hbnu.edu.cn

Preparation and Characterization of Multifunctional Spindle-Shaped Fe3O4@PDA Nanocarriers

WANG Xiaohui1,  LIU Jinglin1,  DING Xin1,2,  HU Yanjun2   

  1. 1. College of Chemistry and Materials Science,  Inner Mongolia University for the Nationalities,  Tongliao 028000,  Inner Mongolia Autonomous Region,   China; 2. Hubei Key Laboratory of Pollutant Analysis & Reuse Technology,  College of Chemistry and Chemical Engineering,  Hubei Normal University,  Huangshi 435002, Hubei Province,  China
  • Received:2025-01-23 Online:2025-09-26 Published:2025-09-26

摘要: 针对聚多巴胺(PDA)基纳米药物载体药物负载率低的共性问题, 合成具有独特梭形结构的Fe3O4@PDA纳米粒子(NPs), 该载体独特的梭形结构可实现高达90%(900 ug/mg)的药物负载率, 显著优于传统PDA基载体. 实验结果表明: 梭形Fe3O4@PDA NPs具有良好的生物相容性、 高效的光热转换能力和优异的近红外(NIR)吸收能力, 可在pH/NIR双响应下控制药物释放; 由于其内嵌Fe3O4, 因此梭形Fe3O4@PDA NPs可作为光声/磁共振成像的对比剂, 用于双模态成像引导的化学-光热协同治疗. 

关键词: 聚多巴胺, 聚乙二醇修饰, 梭形纳米载体

Abstract: Aiming at the common problem of  low drug loading rate of polydopamine (PDA)-based nanocarriers,  we synthesized   Fe3O4@PDA nanoparticles (NPs) with a unique spindle-shaped structure, which could  achieve a drug loading rate of up to 90% (900 ug/mg),  significantly surpassing traditional PDA-based  carriers. The experimental results show that the spindle-shaped Fe3O4@PDA has good  biocompatibility,  efficient photothermal conversion ability,  and excellent  near-infrared (NIR) absorption ability,  which can control  drug release under pH/NIR dual response. Due to its embedded Fe3O4,   spindle-shaped Fe3O4@PDA NPs can be used as  contrast agents for photoacoustic and magnetic resonance imaging, and for  chemo-photothermal synergistic  therapy guided by dual-modal imaging.

Key words:  , polydopamine,  , polyethylene glycol modification, spindle-shaped nanocarrier

中图分类号: 

  • O648