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Two GPX Mimics Protecting Thymocytes from Damage Induced by UV

LV Shao-wu, MU Ying, JI Yue-tong, ZHANG Dai-hui, YAN Gang-lin, LUO Gui-min   

  1. Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130021, China
  • Received:2005-10-11 Revised:1900-01-01 Online:2006-05-26 Published:2006-05-26
  • Contact: YAN Gang-lin

Abstract: Effects of glutathione peroxidase (GPX) mimics (2-seleniumbridgedβ-cyclodextrin, 2-telluriumbridged β-cyclodextrin) on lipidperoxidation, survival ratio, cell cycle and external reactive oxygen species (RO S) content in rat thymocytes, which were radiated by UV-B, were studied invitro. The 2-SeCD and 2-TeCDcan efficiently resist the damage induced by UV. It was found that 2-TeCD possessed a stronger ability to prevent thymocyte from UV-B damage in comparison with 2-SeCD.

Key words: GPX, 2-SeCD, 2-TeCD, mimic, UV

CLC Number: 

  • R392.11