J4 ›› 2010, Vol. 48 ›› Issue (02): 329-332.

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GPX Mimic 6-CySeCD Protecting Mouse Fibroblast |Cell NIH3T3from Damage Induced by H2O2

XU Yawei1,2, YAN Ganglin1, GONG Pingsheng1, MU Ying1, LUO Guimin1, YANG Jia3, LvShaowu1   

  1. 1. Key Laboratory for Molecular Enzymology and Enginnering of Ministry of Education, Jilin University, Changchun 130021, China|2. Department of Bioengineering, Jilin Agricultural Science and Technology College, Jilin 132001, Jilin Province, China|3. Fassino Bio\|Technology Co.Ltd, Changchun 130021, China
  • Received:2009-04-20 Online:2010-03-26 Published:2010-03-22
  • Contact: Lv shao wu E-mail:lvsw@mail.jlu.edu.cn

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Abstract:

The antioxidant effect of 6A,6A′-cyclohexylamine-6B,6B′-seleniumbridged-β-cyclodextrin (6-CySeCD), a new mimic of glutathione peroxidase (GPX), was confirmed with a model system in which mouse fibroblast cell NIH3T3 were damaged by H2O2. The cell damage was characterized in terms of the lipid peroxidation of the cells, cell viability, DNA lysis rate. The injury effects of H2O2 and protection effects of 6-CySeCD on the cells were studied via the model system. The results show the 6CySeCD could be able to protect cells from the damage induced by H2O2.

Key words: glutathione peroxidase (GPX)； mimic； 6CySeCD； hydrogen peroxide, fibroblast cell

CLC Number: 

  • R392.11
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