Abstract:

The genetoxic of polysaccharides from Qiqi Lingzhi physic liquor was studied by mice bone marrow cell micronuclei test, mice testicular chromosome aberration test and Ames test. Acute toxicity test used the method of Huo Enshi. The acute toxicity test of Qiqi Lingzhi polysaccharides showed that the LD50>21 500 mg/kg. Little cytotoxicity was found in the bone marrow cell micronucleus test. No conspicuous teratogenic effect was observed in the test of teratospermia of mice. In the quaque concentration of Ames test, there was no mutagenesis. These results suggest that Qiqi Lingzhi polysaccharides have little toxicity and genetoxic that can be safely used in the longterm.

Key words: polysaccharides, genetoxic, Ames test, micronucleus test, safety