Abstract:

Poly（itaconic acid） was successfully synthesized by radical polymerization. Afterwards, combshape amphiphilic copolymers PIA-g-DDA were obtained via grafting docecylamine onto the backbone of PIA through amination reaction. Hydrodynamic diameter of the micelle formed by PIA-g-DDA in water was recorded by dynamic light scattering (DLS). The effect of graft density of alkyl on the size of the micelle was investigated, with the results indicating that an increase in the graft level of DDA leads to a decrease in the size of the micelle conversely. Critical micelle concentration (CMC) of the micelle was determined through fluorescence spectrophotometry with pyrene as probe to be 2.01×10^-2mg/mL. In the end, the copolymers were employed to encapsulate DOX (DOXorubicin) as a model, namely, drug delivery system PIA-g-DDA@DOX, to demonstrate an ideal encapsulation efficiency and drug loading value, and more importantly sustained release of drugs.

Key words: amphiphilic polymer, poly(itaconic acid), sustainedrelease, doxorubicin