Abstract:

We used CaCO₃ as a template to synthesize hollow mesoporous silica nanoparticles (HMSNs), and characterized the samples by means of transmission electron microscope (TEM) and small angle Xray diffraction (SAXRD). The in vitro biocompatibility and endocytosis properties of HMSNs were detected on A549 cells by flow cytometry. The results show that CaCO_3HMSNs is the nanopartocles, where CaCO₃ is the core and mesoporous silica is the shell; the survival rate of the cells is 100% when the mass concentration of HMSNs is 62.5 μg/mL; the HMSNs materials are absorbed by 92.80% of A549. That is, the HMSNs has a higher endocytosis and biocompatibility.

Key words: hollow mesoporous silica nanoparticles (HMSNs), biocompatibility, endocytosis