Abstract:  Based on gene therapy as a fundamental treatment for diseases, it brings new ideas and methods for the treatment of rheumatoid arthritis (RA). We review  the relevant research advances  of gene therapy for rheumatoid arthritis,  including small interfering RNA (siRNA), micro RNA (miRNA),  DNA,  CRISPR/Cas9 system,  deoxyribonuclease and some other technologies,   providing reference ideas for the application of  gene therapy in the field of RA and offering more  effective and targeted treatment plans for the patients with RA. 

Key words: rheumatoid arthritis, gene therapy, small interfering RNA, micro RNA, DNA origami, CRISPR/Cas9 system