关键词: 甲状腺乳头状微小癌, 细胞凋亡抑制因子, 半乳糖凝集素-3, 甲状腺髓过氧化物酶

Abstract:

Objective  To detect the expressions of survivin,galectin-3(Gal-3) and thyroid peroxidase(TPO) in papillary thyroid microcarcinoma (PTMC) tissue and cancer
adjacent normal tissue,and to explore their clinical significances.Methods  The expressions of survivin,Gal-3 and TPO
 in 56 cases of PTMC tissue and adjacent normal tissue were measured by immunohistochemical (IHC) method;Chi squ
are test was used to compare the differense in the expression rates of survivin,Gal-3 and TPO. The relationships between the ex
pression rates of survivin,Gal-3 and TPO proteins and the clinicopathological parameters of PTMC were analyzed.
Results  The survivin and Gal-3 were strongly expressed but TPO was negatively expressed in PTMC tissue.The survivin and Gal-3
 were negative in adjacent normal tissue but TPO was expressed i  PTMC tissue.There were significant differences in the expression rates of survivin,Gal-3 and TPO between PTMC tissue and adjacent normal tissue (P<0.001).The expression rates of survivin,Gal-3 and TPO in PTMC tissue were positively related  to lymph node metastases (P<0.05, or P<0.01),and were negatively related to gender and age (P>0.05).   Conclusion The strong expressions of survivin and Gal-3 and
 the mild expression of TPO may be important in the development of PTMC, and the detection of survivin,Gal-3 and TPO protein expressions is helpful to jude
 benign and malignant PTMC.

Key words: papillary thyroid microcarcinoma, survivin, galectin-3, thyroid peroxidase