关键词: 心肌梗塞, 心肌酶, 痕量元素, 疾病模型, 动物

Abstract: Objective To examine the effects of Cyclovirobuxinum D sustained-release tablet on the serum enzymes and trace elements and myocardial morphology in acute myocardial infarction dogs. Methods Thirty heterogeneous dogs were divided into five groups (n=6):model group, control group with curative drug,the Cyclovirobuxinum D sustained-release tablet groups with 0.16,0.32 and 0.64 mg·kg^-1, respectively. The changes in the activities of the enzymes and the contents of serum trace elements （Cu²⁺,Zn²⁺,Mg²⁺）were determined in the myocardial infarction models by ligating the left anterior descending branch (LVD) of dogs. The morphological changes of myocardial cells was observed by using HE staining. Results Compared with model group, the activities of AST, CPK, LDH and the content of Cu²⁺ were decreased significantly in the groups with different doses of Cyclovirobuxinum D sustained-release tablet （P<0.05,P<0.01）, whereas the contents of Zn²⁺ and Mg²⁺ were incre ased（P<0.05,P<0.01）. Consequently, Cyclovirobuxinum D sustained-release tablet ameliorated the pathomorphological injury of myocardial cells. Conclusion Cyclovirobuxinum D sustained-release tablet has apparently protective effects on myocardium in canine experimental myocardial infarction models.

Key words: myocardial infarction, myocardial enzymes, trace elements, disease models, animals