阿托伐他汀对家兔动脉粥样硬化模型PPARγ及MMP-9表达的影响

doi:吉林省科技厅资助课题（20050408-3）

阿托伐他汀对家兔动脉粥样硬化模型PPARγ及MMP-9表达的影响

王晓美¹，秦玲¹，李洋¹，黄可欣²

1.吉林大学第一医院心内科，吉林长春 130021；2.吉林大学基础医学院组织学与胚胎学教研室，吉林长春 130021

收稿日期:2006-07-18 修回日期:1900-01-01 出版日期:2007-05-28 发布日期:2007-05-28
通讯作者: 秦玲

Effects of atorvastatin on expressions of peroxisome proliferators- activatedreceptor gamma and MMP-9 in atherosclerosis rabbits

WANG Xiao-mei¹，QIN Ling¹，LI Yang¹，HUANG Ke-xin²

1.Department of Cardiology，First Hospital，Jilin University，Changchun 130021， China; 2.Department of Histology and Embryology，School of Basic Medical Sciences，Jilin University，Changchun 130021，China

Received:2006-07-18 Revised:1900-01-01 Online:2007-05-28 Published:2007-05-28
Contact: QIN Ling

摘要/Abstract

摘要： 目的：研究阿托伐他汀对动脉粥样硬化(AS)组织中过氧化物酶体增殖激活受体γ（PPARγ）和金属蛋白酶-9（MMP-9）表达的影响。方法：将实验动物家兔分为对照组（n=8）、高脂模型组（n=8）和阿托伐他汀干预组（n=8）。高脂模型组用高脂饲料饲养16周，阿托伐他汀干预组除高脂饲养外加用阿托伐他汀；应用免疫组织化学方法观察各组主动脉粥样硬化组织中PPARγ和MMP-9的表达。结果：高脂模型组兔主动脉壁所含PPARγ的阳性标记物百分比（14.38%±2.58%）明显高于对照组（7.82%±0.96%）（P<0.01），所含MMP-9的阳性标记物百分比（17.13%±1.58%）也明显高于对照组（2.72%±0.36%）；阿托伐他汀干预组兔主动脉壁所含PPARγ的阳性标记物百分比（16.11%±2.35%）显著高于高脂模型组（P<0.01），而所含MMP-9的阳性标记物百分比（12.11%±2.05%）低于高脂模型组（P<0.01）。结论：阿托伐他汀增加动脉粥样硬化病变部位PPARγ的表达，抑制MMP-9的表达。

关键词: 氧化物酶体增殖激活受体γ, 金属蛋白酶-9

Abstract: To study the effects of atorvastatin on the expressions of peroxisome proliferators-activated receptor gamma（PPARγ）and matrix metalloproteinase-9（MMP-9）in atherosclerosis（AS） tissue. Methods Atherosclerotic rabbit models on aortas were established with the high-cholesterol diet，and animals were divided into control，model and atorvastatin groups(n=8).The expressions of PPARγ and MMP-9 and the effects of atorvastatin on them were observed by means of immunohistochemistry. Results The expression of PPARγ in model group(14.38%±2.58%)was higher than that in control group（7.82%±0.96%）（P<0.01），and the expression of MMP-9 in model group（17.13%±1.58%）was also higher than that in control group（2.72%±0.36%）（P<0.01）.The expression of PPARγ in atorvastatin group（16.11%±2.35%）was higher than in model group（P<0.01），and the expression of MMP-9 in atorvastatin group（12.11%±2.05%）was lower than that in model group （P<0.01）. Conclusion Atorvastatin can increase the expression of PPARγ and inhibit the expression of MMP-9.These results suggest that atorvastatin has anti-inflammatory effects which are probably related to its activating PPARγ and inhibiting MMP-9.

Key words: peroxisome proliferators-activated receptor gamma, matrix metalloproteinase-9

中图分类号:

R543

王晓美，秦玲，李洋，黄可欣. 阿托伐他汀对家兔动脉粥样硬化模型PPARγ及MMP-9表达的影响[J]. J4, 2007, 33(3): 480-482.

WANG Xiao-mei，QIN Ling，LI Yang，HUANG Ke-xin. Effects of atorvastatin on expressions of peroxisome proliferators- activatedreceptor gamma and MMP-9 in atherosclerosis rabbits[J]. J4, 2007, 33(3): 480-482.

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