关键词: 牙周炎, 大鼠, Wistar

Abstract: Objective To establish a suitable animal model of experimental periodontitis and study the relationship between stress and inflammatory periodontal diseases.Methods Forty Wistar rats with nylon thread placed around the neck of maxillary left second molar tooth were divided randomly into two groups: stress group (the rats were treated with restraint strees for 12 h every day for 10 d) and control group.Four rats of either group were sacrificed at the day of 2,4,6,8,10, separately; the level of blood glucose and the contents of adrenocorticotropic hormone（ACTH）,orticosterone and adrenaline were measured as the stress markers,as well as the relative weight of the thymus and spleen.The furcation area of the second maxillary molar was examined histologically and histometrically.Results In stress group,all the markers for stress were significant higher than those in control group,and the thymus and spleen were atrophied（P<0.05 or P<0.01）.Marked alveolar bone resorption occurred in stress group on the 8th and 10th day（P<0.05or P<0.01）.Conclusion Wistar rat is suitable for establishing the animal model of experimental periodontitis.Restraint stress itself doesn’ t result in periodontitis whereas it modulates the progression of periodontitis.

Key words: periodontitis, rats, Wistar