关键词: 有机提取物, 睾酮, 乳酸脱氢酶, 葡萄糖-6-磷酸脱氢酶, 生殖系统

Abstract: To study the effects of organic extractions from drinking water chlorinated disinfection on the genital system in male mice and provide evidence of safety drinking water for formulating healthy policy. Methods The　 organic extractions from drinking water were enriched by XAD-16 macroporous resin. 40 male mice were divided into 4 groups: control (plant oil +DMSO),high dose organic extractions(500 mg•kg^-1,about equal to 50 L water),middle dose (250 mg•kg^-1),low dose (125 mg•kg^-1). The organic extractions were administered 1 time every day through mouth for 15 d. The testosterone levels in blood serum and testis,the activities of LDH and G-6-PD were measured. Results The testosterone levels in serum and testis in every treatment group were lower than that in control group (P<0.05). In middle and high doses groups,the activities of LDH were lower than those in low dose group and control group obviously (P<0.05).In high dose group,the activity of G-6-PD was higher than those in all the other groups obviously (P<0.05). Conclusion Organic extractions can decrease the activities of G-6-PD and LDH,reduce the testosterone levels in serum and testis,and damage the genital system in male mice.

Key words: organic extractions, testosterone, lactate dehydrogenase, glucose-6-phosphate dehydrogenase , genital system