吉林大学学报(医学版)

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原发性肝细胞癌患者Galectin-3和Galectin-9的表达及其与预后的关系

孔菲1， 马洪喜2，姜 晶1，宋莹1， 郭长松1，金美善2，牛俊奇3   

  1. 1．吉林大学第一医院临床流行病学研究中心，吉林　长春　130021；2．吉林大学第一医院病理诊断中心，吉林　长春　130021；3．吉林大学第一医院肝胆胰内科，吉林　长春　130021
  • 收稿日期:2013-10-19 出版日期:2014-03-28 发布日期:2014-05-28
  • 通讯作者: 金美善（Tel：0431-81875906，E-mail：jimsh88@hotmail.com）； 牛俊奇（Tel：0431-81875101，E-mail：junqiniu@aliyun.com） E-mail:jimsh88@hotmail.com；junqiniu@aliyun.com
  • 作者简介:孔 菲（1986-），女，吉林省吉林市人，在读医学硕士，主要从事病毒性肝炎的临床研究。
  • 基金资助:

    国家自然科学基金资助课题（81001312，81072347，81202377）；吉林省科技厅科研项目资助课题（201215035）

Expressions of Galectin-3 and Galectin-9 in hepatocellular carcinoma patients and their relationship with prognosis

KONG Fei1，MA Hong-xi2，JIANG Jing1，SONG Ying1，GUO Chang-song1， JIN Mei-shan2，NIU Jun-qi3   

  1. 1.Department of Clinical Epidemiology,First Hospital,Jilin University,Changchun 130021,China;2.Department of Pathological Diagnosis,First Hospital,Jilin University,Changchun 130021,China；3.Department of Hepatic-Billary-Pancreatic Medicine,First Hospital,Jilin University,Changchun 130021,China)
  • Received:2013-10-19 Online:2014-03-28 Published:2014-05-28

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摘要：

目的： 探讨原发性肝细胞癌(HCC)患者肿瘤组织及其瘤旁组织中半乳糖凝集素3（Galectin-3）和半乳糖凝集素9（Galectin-9）的表达及其与预后的关系，阐明Galectin-3和Galectin-9在HCC发生发展过程中的意义。方法： 采用免疫组织化学法检测197例HCC患者肿瘤组织和131例瘤旁肝组织中Galectin-3和Galectin-9的表达水平；分析2种蛋白的表达与患者临床病理特征和预后的关系。结果：Galectin-9表达阳性率在HCC肿瘤组织和瘤旁组织中差异无统计学意义（P>0.05），高分化肿瘤组织中Galectin-9表达水平明显高于低分化肿瘤组织（P<0.05），脉管浸润者Galectin-9表达水平低于无脉管浸润者（P<0.05）；Galectin-9高表达患者术后生存时间显著长于低表达和阴性表达患者（P<0.05）。肿瘤组织中Galectin-3表达阳性率显著高于瘤旁组织（P<0.01），但其表达水平与患者各临床病理特征及术后长期生存无关联。调整影响因素后多因素分析，仅丙肝感染（RR=2.86，95%CI：1.13～7.30，P=0.027）、多发肿瘤（RR=2.38，95%CI：1.39～4.07，P=0.002）、肿瘤直径>5 cm（RR=2.13，95%CI：1.21～3.76，P=0.009）和脉管浸润（RR=1.96，95%CI：1.07～3.62，P=0.030）成为影响HCC患者术后长期生存的独立影响因素。结论：Galectin-9表达水平与HCC患者肿瘤组织分化程度和脉管浸润有关联，但Galectin-9和Galectin-3表达水平与HCC患者的预后无关联。

关键词:  , 肝细胞肿瘤, 半乳糖凝集素3, 半乳糖凝集素9, 预后

Abstract:

Objective To investigate the  expressions of Galectin-3 and Galectin-9 in  the tumor tissue and adjacent cancer tissue of the patients with hepatocellular carcinoma (HCC) and their relationship with prognosis,and to explore the significance of Galectin-3 and Galectin-9 in the occurrence and development of HCC.Methods The expressions of Galectin-3 and Galectin-9 in 197 cases of HCC tissue  and 131 cases of adjacent cancer  tissue were detected by immunohistochemical technique;the association between the  expressions of Galectin-3 and Galectin-9 and  the  clinicopathologic characteristics  and prognosis of HCC patients were analyzed.Results There was no significant difference of the positive expression rate of Galectin-9 between HCC tumor tissue and adjacent cancer tissue (P>0.05).The expression levels of Galectin-9 in the  patients with  poorly differentiated HCC  or  with lymph-vascular invasion were lower than those in the  patients with well differentiated HCC  or  without lymph-vascular invasion (P<0.05);the patients with a high-level expression of Galection-9 showed a longer survival period compared with those with negative and low-level expression of Galectin-9 (P<0.05).The positive expression rate of Galectin-3 in HCC tumor tissue was significant higher than that in adjacent cancer tissue (P<0.01).The expression level of Galectin-3 in HCC tissue was not related to the clinicopathologic characteristics  and prognosis of the patients.After adjusting the influencing factors,the multivariate analysis results showed only the infection of hepatitisc (RR=2.86,95%CI：1.13-7.30,P=0.027),multiple tumor (RR=2.38,95%CI：1.39-4.07,P=0.002),diameter of tumor>5 cm (RR=2.13,95%CI：1.21-3.76,P=0.009), and lymph-vascular invasion(RR=1.96,95%CI：1.07-3.62,P=0.030) were the independent influencing factors of prognosis of the HCC patients.Conclusion The expression level of Galectin-9 is related to the tumor differentiation and lymph-vascular invasion of the HCC patients,and the expression levels of Galectin-3 and Galectin-9 are not associated with the prognosis  of HCC patients.

Key words:  , hepatocellular carcinoma, Galectin-3, Galectin-9, prognosis

中图分类号: 

  • R575 
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