膀胱移行细胞癌中MMP-2的表达

doi:教育部重点项目资助课题

膀胱移行细胞癌中MMP-2的表达

王医术¹，那万里²，周洪澜^2*，李一雷¹，王心蕊¹，李玉林¹

1.吉林大学基础医学院病理生物学实验室，吉林长春130021；2.吉林大学中日联谊医院泌尿外科，吉林长春130031

收稿日期:2003-12-26 修回日期:1900-01-01 出版日期:2005-01-28 发布日期:2005-01-28

Expression of matrix metalloproteinases-2 in transitionalcell carcinoma of bladder and its clinical significance

WANG Yi-shu¹,NA Wan-li²,ZHOU Hong-lan^2,LI Yi-lei¹, WANG Xin-rui¹，LI Yu-lin¹

1. Department of Pathobiological Laboratory,School of Basic Medical Sciences, Jilin University,Changchun 130021,China;2. Department of Urology, China-Japan Union Hospital, Jilin University, Changchun 130031, China

Received:2003-12-26 Revised:1900-01-01 Online:2005-01-28 Published:2005-01-28

摘要/Abstract

摘要： 目的：探讨基质金属蛋白酶2（MMP-2）在膀胱移行细胞癌(TCCB)中的表达及意义。方法：采用免疫组织化学和原位杂交方法检测60例不同病理分期、分级的TCCB组织中MMP-2的表达情况，同时取5例正常膀胱组织作为对照。结果：MMP-2蛋白在间质细胞中表达远多于肿瘤细胞，在肿瘤细胞中仅呈散在表达且表达较弱；MMP-2 mRNA在间质细胞和肿瘤细胞均有表达；在正常膀胱组织中MMP-2不表达或呈分布均匀的微量表达；随着TCCB临床病理分期、分级的升高，MMP-2表达呈现增高趋势（P<0.01）。结论：MMP-2在TCCB组织中表达并且与肿瘤的浸润和转移能力有关。

关键词: 膀胱移行细胞癌, 明胶酶A, 肿瘤侵润, 肿瘤转移

Abstract: Objective To study the expressions of matrix metalloproteinases-2 (MMP-2) in different grade and stage of transitional cell carcinoma of bladder（TCCB） and its significance. Methods Immunohistochemistry and in situ hybridization were used in 60 surgically resected specimens from patients with TCCB and 5 normal bladder tissues (used as control) to detect the expression of MMP-2. Results MMP-2 protein appeared to be far more abundant in stromal cells than tumor cells; MMP-2 mRNA appeared in stromal cells and tumor cells; in control group, the expression of MMP-2 was weak or negative; the positive expression of MMP-2 was significantly increased with stage and grade (P<0.01,respectively). Conclusion MMP-2 can express in TCCB and the expression of MMP-2 is significantly correlated with the aggressive and metastatic biologic behavior of TCCB.

Key words: transitional cell carcinoma of bladder, gelatinase A, neoplasm invasiveness, neoplasm metastasis

中图分类号:

R737.14

王医术，那万里，周洪澜，李一雷，王心蕊，李玉林. 膀胱移行细胞癌中MMP-2的表达[J]. J4, 2005, 31(1): 91-93.

WANG Yi-shu,NA Wan-li,ZHOU Hong-lan,LI Yi-lei, WANG Xin-rui，LI Yu-lin. Expression of matrix metalloproteinases-2 in transitionalcell carcinoma of bladder and its clinical significance[J]. J4, 2005, 31(1): 91-93.

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