关键词: 肝细胞, 明胶酶A, 血液, 明胶酶A, 化学, 明胶酶B, 血液, 明胶酶B, 化学, 肿瘤侵润, 肿瘤转移

Abstract: Objective To investigate the correlations of serum matrix metalloproteinase-2,-9 (MMP-2,MMP-9) contents and tissue expressions in hepatocel lular carcinoma with tumor invasion and metastasis. Methods Serum MMP-2,MMP-9 contents were detected in 40 patie nt with hepatocellular carcinoma and 20 healthy controls by ELISA; the expressi ons and distributions of MMP-2 and MMP-9 in 40 patients and 10 normal tissues were detected by immunohistochemical method. Results Serum MMP-2,MMP-9 contents were significantly elevated in cancer samples compared with normal serum (P<0.01), the significant difference was found between contents in the presence and the absence of lymph node metastasis (P<0.05).In hepatocellular carcinoma, the expressions of MMP-2,MMP-9 were increased significantly compared with normal tissue.The expressions of MMP-2,MMP-9 were correlated with histological grade and lymph node metast asis (P<0.05). Conclusion The serum of MMP-2 and MMP-9 contents and their expressions may pr ovide reliable information for hepatocellular carcinoma prognosis.

Key words: hepatocellular, gelatinase A, blood, gelatinase A, chemistry, gelatinase B, blood, gelatinase B, chemistry, neoplasm invasion, neoplasm metastasis