短期持续皮下胰岛素输注治疗初诊2型糖尿病的随访分析

doi:吉林省科技厅资助课题(20050413-03)

短期持续皮下胰岛素输注治疗初诊2型糖尿病的随访分析

孙亚东，马彦，阚英，邵红，韩艳，关红，杨乐

吉林省人民医院内分泌科，吉林长春 130021

收稿日期:2006-12-05 修回日期:1900-01-01 出版日期:2007-05-28 发布日期:2007-05-28
通讯作者: 孙亚东

Follow-up analysis of short-term continuous subcutaneous insulin infusion therapy for newly diagnosed type 2 diabetes mellitus

SUN Ya-dong,MA Yan, KAN Ying, SHAO Hong, HAN Yan, GUAN Hong, YANG Le

Department of Endocrinology, People’s Hospital of Jilin Province, Changchun 130021, China

Received:2006-12-05 Revised:1900-01-01 Online:2007-05-28 Published:2007-05-28
Contact: SUN Ya-dong

摘要/Abstract

摘要： 目的：观察短期持续皮下胰岛素输注（CSII）对初诊2型糖尿病（T2DM）血糖控制的效果。方法：对179例初诊T2DM患者进行CSII治疗3周。以静脉葡萄糖耐量试验（IVGTT）对患者进行治疗前后自身对照，分析比较血糖（BG）、糖化血红蛋白（HbA_1c）、岛素（INS）C肽(C-P）的变化。停止治疗后0、3及8周分别重复监测上述指标。结果：纳入分析的159例患者应用CSII治疗前血糖控制均很差，平均空腹血糖（FPG）为（15.27±2.32）mmol•L^-1，餐后血糖（PPG）为（22.18±3.43）mmol•L^-1HbA_1c为14.95%±2.42%。CSII治疗3周结束时，FPG、PPG和HbA_1c均较治疗前明显下降，分别为（5.52±1.30）mmol•L^-1、（7.18±1.21）mmol•L^-1和10.86%±1.33%(P<0.001或P<0.05)。患者不同程度地恢复了胰岛素（INS）分泌第一时相。在CSII治疗停止后3及8周，FPG、PPG和HbA_1c较治疗前明显降低(P<0.001或P<0.05)。结论：初诊T2DM患者经CSII强化治疗3周有效者血糖得到良好控制。

关键词: 非胰岛素依赖型, 持续皮下胰岛素输注, 葡糖耐量试验

Abstract: Abstract:Objective To observe the effects of glycemic control in patients with newly diagnosed type 2 diabetes mellitus(T2DM) by continuous subcutaneous insulin infusion (CSII). Methods A total of 179 patients with newly diagnosed T2DM received 3 weeks’ treatment of CSII. Before-after study in the same patient was applied. Intravenous glucose tolerance test (IVGTT) was performed, and blod glucose, HbA_1c, insulin, C-peptide (C-P) were measured before and after CSII. The same index was observed 3 and 8 weeks after drug withdrawal. Results Of  all 179 patients,159 cases were chosen. Before CSII, the average fasting plasma glucose (FPG) was (15.27±2.32)mmol•L^-1, postprandial plasma glucose (PPG)was (22.18±3.43)mmol•L^-1, and HbA_1c was 14.95%±2.42%. 3 weeks after CSII, FPG, PPG and HbA1c were significantly decreased［(5.52±1.30)mmol•L^-1，(7.18±1.21)mmol•L^-1 and 10.86%±1.33%, respectively］(P<0.001 or P<0.05). The patients had different degree restoration of the first-phase insulin secretion. 3 and 8 weeks after drug withdrawal, FPG, PPG and HbA_1c were significantly reduced (P<0.001 or P<0.05). Conclusion The excellent glycemic control can be induced by 3 weeks’ treatment of CSII in newly diagnosed T2DM.

Key words: non-insulin-dependent, continuous subcutaneous insulin infusion, glucose tolerance test

中图分类号:

R587.1

孙亚东，马彦，阚英，邵红，韩艳，关红，杨乐. 短期持续皮下胰岛素输注治疗初诊2型糖尿病的随访分析[J]. J4, 2007, 33(3): 591-594.

SUN Ya-dong,MA Yan, KAN Ying, SHAO Hong, HAN Yan, GUAN Hong, YANG Le. Follow-up analysis of short-term continuous subcutaneous insulin infusion therapy for newly diagnosed type 2 diabetes mellitus[J]. J4, 2007, 33(3): 591-594.

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